Nestin, PDGFRβ, CXCL12 and VEGF in glioma patients -: Different profiles of (pro-angiogenic) molecule expression are related with tumor grade and may provide prognostic information
Nestin, PDGFRβ, CXCL12 and VEGF in glioma patients -: Different profiles of (pro-angiogenic) molecule expression are related with tumor grade and may provide prognostic information
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DOI：
10.4161/cbt.6.7.4362
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发表时间：
2007-07-01
影响因子：
3.6
通讯作者：
Pollo, Bianco
中科院分区：
文献类型：
--
作者：
Maderna, Ernanuela;Salmaggi, Andrea;Pollo, Bianco
血管生成是胶质瘤自然发展过程中的关键事件。Nestin是多潜能神经上皮干细胞的标志物，在神经上皮肿瘤和增殖内皮细胞（ECs）中检测到，并参与谱系承诺、增殖和分化的早期阶段。Nestin的表达与促血管生成趋化因子（CXCL12及其受体CXCR4）和生长因子（VEGF、PDGF-B及其受体PDGFR β）相关。VEGF表达上调内皮细胞上的CXCR4，结合对内皮细胞血管生成和趋化有作用的趋化因子SDF1/CXCL12（基质衍生因子）；PDGF（血小板衍生生长因子）和PDGFR β通过增加VEGF的表达也至关重要。我们对102例胶质瘤患者中巢蛋白表达细胞的存在和作用进行了回顾性研究，将研究结果与VEGF、CXCL12、PDGFR β表达和临床结果（肿瘤进展时间- ttp和生存时间- st）联系起来。我们的研究结果表明，在胶质瘤中，表达巢蛋白的增殖内皮细胞的检测与组织学恶性程度和临床结果相关。此外，CXCL12在低级别胶质瘤中的表达是唯一与TTP显著缩短相关的因素，这表明该趋化因子在血管生成转移和/或疾病进展中起作用。
Angiogenesis is a key event in the natural progression of gliomas. Nestin, a marker for multipotential neuroepithelial stem cells, is detected in neuroepithelial tumors and in proliferating endothelial cells (ECs) and is involved in the early stages of lineage commitment, proliferation and differentiation. Nestin expression is correlated with proangiogenic chemokines (CXCL12 and its receptor CXCR4) and growth factors (VEGF, PDGF-B and its receptor PDGFR beta).VEGF expression upregulates CXCR4 on endothelial cells, binding the chemokine SDF1/CXCL12 (Stromal Derived Factor) that has a role on angiogenesis and chemotaxis of endothelial cells; PDGF (platelet-derived growth factor) and PDGFR beta are also crucial by increasing the expression of VEGF.We performed a retrospective study on the presence and role of nestin-expressing cells in 102 patients with glioma, relating the findings to VEGF, CXCL12, PDGFR beta expression and to clinical outcome (time to tumor progression-TTP and survival time-ST).Our results suggest that in gliomas the detection of proliferating ECs expressing nestin correlates to histological malignancy grade and clinical outcome. Also, the expression of CXCL12 in low-grade gliomas was the only factor associated with a significantly shorter TTP, suggesting a role of this chemokine in ongiogenic shift and/or disease progression.