Testosterone and cardiovascular risk in patients with erectile dysfunction
Testosterone and cardiovascular risk in patients with erectile dysfunction
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勃起功能障碍患者的睾酮水平和心血管风险
DOI：
10.3275/8063
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发表时间：
2011
影响因子：
5.4
通讯作者：
Mario Maggi
中科院分区：
文献类型：
--
作者：
Giovanni Corona;G. Rastrelli;G. Balercia;A. Sforza;G. Forti;Mario Maggi
背景：男性心血管（CV）疾病（CVD）与睾酮（T）水平之间的关系尚未完全阐明。目的：评价勃起功能障碍（艾德）受试者中T水平与CV风险之间的相关性，并验证其体重指数（BMI）是否可能代表T相关CV分层中的可能混杂因素。材料和方法：2269例男性患者参加门诊艾德连续系列进行了研究。使用来自Progetto Cuore研究的引擎评价CV风险评估。结果如下：调整BMI和相关发病率后，SHBG结合和未结合T水平作为通过Progetto Cuore风险引擎评估的CV风险的函数降低。此外，性腺功能减退相关症状和体征的患病率较高与CV风险较高相关。在Progetto Cuore风险引擎中包括的因素中，年龄、总胆固醇和HDL胆固醇以及糖尿病均与总游离T水平和计算游离T水平的CV风险依赖性改变显著相关。当SHBG结合和未结合T与CV风险之间的关系作为肥胖的函数（BMI>30 kg/m2）进行评估时，所有上述相关性仅在非肥胖患者中得到证实。结论：性腺功能减退可能与CV风险增加或降低相关，这取决于受试者的特征。在肥胖患者中观察到的低T可能代表较高的CV风险的结果，而不是直接的发病机制。
Background: The relationship between cardiovascular (CV) diseases (CVD) and testosterone (T) levels in men has not been completely clarified. Aim: To evaluate the association between T levels and CV risk in subjects with erectile dysfunction (ED) and to verify whether their body mass index might (BMI) represents a possible confounder in T-related CV stratification. Material and methods: A consecutive series of 2269 male patients attending the Outpatient Clinic for ED was studied. The assessment of CV risk was evaluated using the engine derived from the Progetto Cuore study. Results: After adjustment and for BMI and associated morbidities, SHBG-bound and -unbound T levels decreased as a function of CV risk assessed thorough Progetto Cuore risk engine. In addition, a higher prevalence of hypogonadism related symptoms and signs was associated with a higher CV risk. Among factors included in the Progetto Cuore risk engine age, total and HDL cholesterol and diabetes were all significantly associated with CV risk-dependent modification of total and calculated free-T levels. When the relationship between SHBG bound and unbound T and CV risk was evaluated as a function of obesity (BMI>30 kg/m2), all the aforementioned associations were confirmed only in non obese patients. Conclusions: Hypogonadism could be associated either with an increased or reduced CV risk, depending on the characteristics of subjects. Low T observed in obese patients might represent the result of higher CV risk rather than a direct pathogenetic mechanism.
DOI：
10.1210/jcem.84.10.6079
发表时间：
1999-10
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
A. Vermeulen;Lieve Verdonck;Jean Kaufman
通讯作者：
A. Vermeulen;Lieve Verdonck;Jean Kaufman