Parasite multiplication potential and the severity of falciparum malaria
Parasite multiplication potential and the severity of falciparum malaria
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DOI：
10.1086/315353
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发表时间：
2000-03-01
影响因子：
6.4
通讯作者：
White, NJ
中科院分区：
文献类型：
--
作者：
Chotivanich, K;Udomsangpetch, R;White, NJ
为了模拟重度疟疾和控制宿主效应，将泰国成年无并发症疟疾患者(n=34)和重度疟疾患者(n=42)的恶性疟原虫分离株的增殖率和侵袭力进行了比较。来自重度疟疾患者的恶性疟原虫分离株在体外的初始周期增殖率是无并发症疟疾患者的3倍(中位数为8.3[95%可信区间]，8.3[7.1-10.5]比2.8[1.7-3.9]；P=.001)，引起严重疟疾患者的寄生虫表现出不受限制的红细胞入侵，而来自无并发症疟疾患者的恶性疟原虫红细胞的几何平均值仅为40(31%-53%)。与引起简单疟疾的恶性疟原虫相比，引起严重疟疾的恶性疟原虫选择性较低，在高寄生率时繁殖更多。
The multiplication rates and invasiveness of Plasmodium falciparum parasites isolated from adult Thai patients hospitalized with uncomplicated malaria (n = 34) were compared with those from persons with severe malaria (n = 42), To simulate severe malaria and control for host effects, the in vitro cultures were adjusted to 1% parasitemia and used the same red blood cell donor. P. falciparum isolates from persons with severe malaria had initial cycle multiplication rates in vitro that were 3-fold higher than those from uncomplicated malaria (median [95% confidence interval], 8.3 [7.1-10.5] vs. 2.8 [1.7-3.9]; P = .001), Parasites causing severe malaria exhibited unrestricted red blood cell invasion, whereas those from uncomplicated malaria were restricted to a geometric mean of 40 (31%-53%) of red blood cells. P. falciparum parasites causing severe malaria were less selective and multiplied more at high parasitemias than those causing uncomplicated malaria.