NEUROGENESIS OF MOTONEURONS IN THE SEXUALLY DIMORPHIC SPINAL NUCLEUS OF THE BULBOCAVERNOSUS IN RATS
NEUROGENESIS OF MOTONEURONS IN THE SEXUALLY DIMORPHIC SPINAL NUCLEUS OF THE BULBOCAVERNOSUS IN RATS
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DOI：
10.1016/0165-3806(83)90106-2
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
ARNOLD, AP
中科院分区：
文献类型：
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作者：
BREEDLOVE, SM;JORDAN, CL;ARNOLD, AP
雄性大鼠球海绵体脊髓核（SNB）由支配会阴横纹肌的运动神经元组成。成年SNB运动神经元的数量可以增加或减少围产期操作雄激素或抗雄激素。目前的结果与胸苷放射自显影表明，SNB运动神经元进行最后的有丝分裂的第14天妊娠。因为雄性大鼠的睾酮产生直到妊娠第14天后才开始，雄激素不太可能影响正常雄性大鼠的SNB神经发生。推而广之，> 1周后影响SNB细胞数量的激素操作可能是由细胞死亡或特化的改变介导的，而不是它们的增殖。
The spinal nucleus of the bulbocavernous (SNB) consists of motoneurons innervating striated perineal muscles in male rats. The adult number of SNB motoneurons can be increased or decreased by perinatal manipulations with androgen or anti-androgen. The present results with thymidine autoradiography demonstrate that SNB motoneurons undergo their final mitosis on the 14th day of gestation. Because testosterone production in male rats does not begin until after gestational day 14, androgens are unlikely to affect SNB neurogenesis in normal males. By extension, hormonal manipulations > 1 wk later, which affect the number of SNB cells, are probably mediated by alterations in the death or specification of cells, but not their proliferation.