Arterial wall changes in early human vasospasm.
Arterial wall changes in early human vasospasm.
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DOI：
10.1227/00006123-198502000-00008
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发表时间：
1985-02
期刊：
影响因子：
4.8
通讯作者：
R R Smith-R;B. Clower;G M Grotendorst;N. Yabuno;J. M. Cruse
中科院分区：
文献类型：
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作者：
R R Smith-R;B. Clower;G M Grotendorst;N. Yabuno;J. M. Cruse
对3例近期蛛网膜下腔出血患者的脑动脉进行了组织学、组织化学和组织免疫学研究。血管痉挛的严重程度与病理改变的程度之间似乎存在相关性。内层肌成纤维细胞和V型胶原在明显收缩的血管中大量存在，但在受累较轻的动脉中不太明显。非脑性死亡患者的颅内动脉未表现出这些变化。因此，肌成纤维细胞和V型胶原蛋白可能与脑血管痉挛有关，在愈合期间使受损血管处于收缩期数周。
Histological, histochemical, and histoimmunological studies were conducted on cerebral arteries from three living patients with a recent subarachnoid hemorrhage. There seemed to be a correlation between the severity of vasospasm and the magnitude of pathological alterations. Myofibroblasts and Type V collagen within the medial layer were abundant in vessels showing marked constriction, but were less conspicuous in those arteries showing milder involvement. Intracranial arteries from patients who died from noncerebral causes did not demonstrate these changes. Thus, myofibroblasts and Type V collagen may be related to cerebral vasospasm by holding the damaged vessel in a contracted phase for weeks during the healing period.