Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men.
Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men.
复制标题
DOI：
10.2147/ott.s96294
复制
发表时间：
2016
影响因子：
4
通讯作者：
Ye D
中科院分区：
文献类型：
--
作者：
Zhang G;Zhu Y;Liu F;Gu C;Chen H;Xu J;Ye D
越来越多的证据表明，胰岛素样生长因子结合蛋白-3（IGFBP-3）多态性与前列腺癌（PCa）的风险改变有关。然而，很少有研究在中国人群中进行，以验证这种关联。在此，我们基于全基因组关联研究（1，417例病例和1，008例对照）检查了中国汉族人群中IGFBP-3基因的遗传变异与PCa风险之间的关联，并使用Sequenom平台在独立的病例对照研究（1，755例病例和1，523例对照）中复制了三个遗传变异位点。进行逻辑回归分析以估计比值比（OR）和95%置信区间（95%CI）。发现阶段rs 9691259（OR =0.691，95%CI：0.587-0.814，P<0.001）和rs6950179（OR =1.420，95%CI：1.201-1.677，P<0.001）与PCa风险显著相关，而rs 2854744与PCa风险边缘相关。在复制阶段，rs 9691259和rs6950179与PCa风险之间的关联未被复制，而rs 2854744赋予与PCa风险的显著关联（OR =1.399，95%CI：1.010-1.937，P=0.043）。结合两个阶段后，我们发现rs 9691259，rs6950179和rs 2854744都与PCa风险显著相关。这项研究表明IGFBP-3基因变异与中国人群中PCa风险显著相关。
Growing evidence has indicated that insulin-like growth factor binding protein-3 (IGFBP-3) polymorphisms are associated with altered risk of prostate cancer (PCa). However, few studies have been conducted in Chinese population to validate this association. Herein, we examined the association between genetic variants in the IGFBP-3 gene and PCa risk in the Chinese Han population based on a genome-wide association study (1,417 cases and 1,008 controls), and replicated three genetic variants loci in an independent case-control study (1,755 cases and 1,523 controls) using Sequenom platform. Logistic regression analyses were performed to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). We found that in the discovery stage, rs9691259 (OR =0.691, 95% CI: 0.587–0.814, P<0.001) and rs6950179 (OR =1.420, 95% CI: 1.201–1.677, P<0.001) were significantly associated with PCa risk, whereas rs2854744 showed a marginal association with PCa risk. In the replication stage, the association between rs9691259 and rs6950179 and PCa risk was not replicated, whereas rs2854744 conferred a significant association with PCa risk (OR =1.399, 95% CI: 1.010–1.937, P=0.043). After combining the two stages, we found that rs9691259, rs6950179, and rs2854744 were all significantly associated with PCa risk. This study suggests that IGFBP-3 genetic variants are significantly associated with PCa risk in the Chinese population.