Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
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DOI：
10.1038/s41598-018-27101-0
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发表时间：
2018-06-07
影响因子：
4.6
通讯作者：
Corbett, Dale
中科院分区：
文献类型：
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作者：
Balbinot, Gustavo;Schuch, Clarissa Pedrini;Corbett, Dale
多肌肉激活的协调模式对于产生有效的到达轨迹至关重要。这些协调激活模式的破坏，称为协同作用，在中风后是明显的，并导致到达缺陷;然而，这种现象的临床前研究在很大程度上被忽视了。此外，传统的中风后表现的结果测量很少区分损伤恢复和补偿性运动策略。我们试图解决这一问题，通过使用运动学分析来表征达到运动和运动学协同作用的大鼠执行蒙托亚楼梯任务，缺血性中风之前和之后。协同作用被定义为在伸展过程中手腕和其他近端前肢关节（即肩、肘）的同时运动。中风后，大鼠关节间的个体化程度降低，患肢更多地作为一个整体移动。此外，异常屈肌协同作用的特点是并发肘屈曲，肩内收，外旋是显而易见的。这些异常最终导致低效和不稳定的到达轨迹，并降低了到达性能（弹丸回收）。在该临床前卒中模型中观察到的到达异常与在人类中观察到的经典异常相似。这突出了运动学分析的潜力，以更好地调整临床前和临床结果的措施，这是必不可少的制定未来的康复策略后中风。
A coordinated pattern of multi-muscle activation is essential to produce efficient reaching trajectories. Disruption of these coordinated activation patterns, termed synergies, is evident following stroke and results in reaching deficits; however, preclinical investigation of this phenomenon has been largely ignored. Furthermore, traditional outcome measures of post-stroke performance seldom distinguish between impairment restitution and compensatory movement strategies. We sought to address this by using kinematic analysis to characterize reaching movements and kinematic synergies of rats performing the Montoya staircase task, before and after ischemic stroke. Synergy was defined as the simultaneous movement of the wrist and other proximal forelimb joints (i.e. shoulder, elbow) during reaching. Following stroke, rats exhibited less individuation between joints, moving the affected limb more as a unit. Moreover, abnormal flexor synergy characterized by concurrent elbow flexion, shoulder adduction, and external rotation was evident. These abnormalities ultimately led to inefficient and unstable reaching trajectories, and decreased reaching performance (pellets retrieved). The observed reaching abnormalities in this preclinical stroke model are similar to those classically observed in humans. This highlights the potential of kinematic analysis to better align preclinical and clinical outcome measures, which is essential for developing future rehabilitation strategies following stroke.