DICARBANONABORATES - NEW INHIBITORS OF MITOCHONDRIAL L-GLYCEROL-3-PHOSPHATE DEHYDROGENASE
DICARBANONABORATES - NEW INHIBITORS OF MITOCHONDRIAL L-GLYCEROL-3-PHOSPHATE DEHYDROGENASE
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DOI：
10.1006/bbrc.1995.1724
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发表时间：
1995-05-25
影响因子：
3.1
通讯作者：
KALOUS, M
中科院分区：
文献类型：
--
作者：
DRAHOTA, Z;SAF, P;KALOUS, M
测试巯基-和氯-二碳基硼酸盐对线粒体、FAD-连接的L-甘油-3-磷酸脱氢酶活性的抑制作用。发现巯基二碳基硼酸盐是比氯衍生物更有效的抑制剂。巯基和氯代二碳基硼酸酯的K_i分别为0.8M和480 M，巯基二碳基硼酸酯对酶的抑制作用为竞争性，氯代衍生物的抑制作用为非竞争性。加入牛血清白蛋白可完全阻止巯基二碳硼酯的抑制作用。(C)学术出版社
The inhibitory effect of mercapto- and chloro-dicarbanonaborates on mitochondrial, FAD-linked, L-glycerol-3-phosphate dehydrogenase activity was tested. The mercaptodicarbanonaborate was found to be a more potent inhibitor than the chloro derivative. The K-i of mercapto- and chlorodicarbanonaborates were 0.8 M and 480 M, respectively.Whereas the mercaptodicarbanonaborate inhibited the enzyme activity competitively, the inhibitory effect of chloro derivative was noncompetitive. The inhibitory effect of mercaptodicarbanonaborate was completely prevented by addition of bovine serum albumin. (C) Academic Press, Inc.