Downregulation of the major histocompatibility complex class I molecules by human herpesvirus type 8 and impaired natural killer cell activity in primary effusion lymphoma development
Downregulation of the major histocompatibility complex class I molecules by human herpesvirus type 8 and impaired natural killer cell activity in primary effusion lymphoma development
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人疱疹病毒 8 型下调主要组织相容性复合物 I 类分子并损害原发性渗出性淋巴瘤发展中的自然杀伤细胞活性
DOI：
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发表时间：
2005
影响因子：
6.5
通讯作者：
B. Ensoli
中科院分区：
文献类型：
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作者：
M. Sirianni;Fabio Libi;M. Campagna;D. Rossi;D. Capello;G. Sciaranghella;A. Carbone;C. Simonelli;P. Monini;G. Gaidano;B. Ensoli
原发性渗出性淋巴瘤(PEL)多为人类8型疱疹病毒(HHV8)感染，常合并EB病毒(EBV)感染。我们发现，与HHV8阴性淋巴瘤相比，PEL细胞主要组织相容性复合体I类(MHC-I)表面分子的表达显著减少，与EBV感染无关。MHC-I的下调使PEL细胞对自然杀伤(NK)细胞的识别和杀伤敏感。有趣的是，对两名PEL患者进行的MHC-I非限制性细胞毒性分析显示，与健康人相比，NK细胞活性降低。这些数据表明，PEL的生长可能需要受损的NK细胞功能。
Primary effusion lymphomas (PELs) are invariably infected by human herpesvirus type 8 (HHV8) and often co‐infected by Epstein–Barr virus (EBV). We found that expression of major histocompatibility complex class I (MHC‐I) surface molecules was significantly decreased in PEL cells when compared with HHV8 negative lymphomas, irrespective of EBV infection. MHC‐I downregulation rendered PEL cells sensitive to recognition and killing by natural killer (NK) cells. Intriguingly, analysis of MHC‐I non‐restricted cytotoxicity in two PEL patients indicated a reduced NK cell activity when compared with healthy individuals. These data suggest that PEL outgrowth may require an impaired NK cell function.