Total synthesis of lamellarins D, L, and N
Total synthesis of lamellarins D, L, and N
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DOI：
10.1016/j.tet.2005.10.014
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发表时间：
2006-01-23
期刊：
影响因子：
2.1
通讯作者：
Iwao, M
中科院分区：
文献类型：
--
作者：
Fujikawa, N;Ohta, T;Iwao, M
以hinsberg型吡咯合成和钯催化的Suzuki-Miyaura偶联3,4-二羟吡咯酯6为关键反应，合成了具有细胞毒性的海洋生物碱片层素D、L和N。普通中间体6的片层素D、L和N的总产率分别为54%、58%和50%。(c) 2005 Elsevier Ltd版权所有。
Total synthesis of cytotoxic marine alkaloids, lamellarins D, L, and N, has been achieved by using Hinsberg-type pyrrole synthesis and palladium-catalyzed Suzuki-Miyaura coupling of the 3,4-dihydroxypyrrole bistriflate 6 as the key reactions. The total yields of lamellarins D, L, and N from the common intermediate 6 are 54, 58, and 50%, respectively. (c) 2005 Elsevier Ltd. All rights reserved.