Regeneration of periodontal ligament and cementum by BMP-applied tissue engineering.
Regeneration of periodontal ligament and cementum by BMP-applied tissue engineering.
复制标题
应用 BMP 的组织工程实现牙周膜和牙骨质的再生。
DOI：
10.1111/j.1600-0722.1998.tb02176.x
复制
发表时间：
1998
影响因子：
1.9
通讯作者：
H. Kato
中科院分区：
文献类型：
--
作者：
Y. Kuboki;M. Sasaki;A. Saito;H. Takita;H. Kato
以前，我们证明骨形态发生蛋白(BMP)的诱导特性高度依赖于用于植入的载体材料的性质。在这篇文章中，我们证明了将BMP结合到纤维胶原膜中可以帮助猫和猴子磨牙的牙周膜和牙骨质再生。将部分纯化的牛骨形成蛋白与一层或两层纤维性胶原膜结合。虽然单层方法显示牙周部分再生，但它也经常导致牙周僵硬。用双层技术修复人工制备的猴恒磨牙III类根分叉，取得了良好的效果。12wk后，牙槽突、牙周膜和牙骨质沿整个牙本质表面再生。胶原纤维大致垂直于新生牙骨质表面排列。未见关节强直。结论：双层法在牙骨质再生方面优于单层法。
Previously, we demonstrated that the inductive properties of bone morphogenetic protein (BMP) highly depend on the nature of the carrier material used for implantation. In this paper, we show that administration of BMP incorporated in a fibrous collagen membrane can help to regenerate periodontal ligament and cementum both in cat canines and in monkey molars. The partially purified bovine BMP was combined with one or two layers of a fibrous collagen membrane. Although the single layer approach showed partial regeneration of periodontal defects, it also quite often led to ankylosis. The double layer technique in artificially prepared class III furcation defects in monkey molars gave favorable results. After 12 wk, not only the alveolar process but also the periodontal ligament and cementum had regenerated along the entire treated dentin surface. Collagen fibers were arranged more or less perpendicular to the surface of the new cementum. Ankylosis was not seen. It is concluded that the double-layer approach is superior to the single-layer technique in regenerating cementum.