CD4+CD8+double positive (DP) T cells in health and disease
CD4+CD8+double positive (DP) T cells in health and disease
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DOI：
10.1016/j.autrev.2003.09.001
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发表时间：
2004-03-01
影响因子：
13.6
通讯作者：
Chizzolini, C
中科院分区：
文献类型：
--
作者：
Parel, Y;Chizzolini, C
成熟T细胞上CD4和CD8 α共受体的表达通常被认为是相互排斥的，并反映了亚群相关的特异性功能（辅助与细胞溶解）和抗原识别的主要组织相容性复合物限制的差异。然而，表达CD4和CD8的双阳性（DP）T细胞已经在几种病理状况以及正常个体中被描述。DP T细胞代表异质群体。强有力的证据表明，体内终末分化的效应CD4可以获得CD8的α链。反过来，在体外活化的CD8+ T细胞的结果在低水平的CD4的表达，可能介导的HIV进入和对趋化细胞因子的反应。特别有趣的是，在自身免疫性和慢性炎症性疾病中已经鉴定出表达高水平的CD4和CD8 α异二聚体（CD4（hi）CD8（hi））的DP T细胞亚群。虽然没有明确的证据，但可以推测，由于错误的胸腺选择，CD4（hi）CD8（hi）T细胞可能具有自身反应性。(C)2003 Elsevier B.V.保留所有权利。
The expression of CD4 and CD8alphabeta co-receptors on mature T cells is generally considered to be mutually exclusive and reflects subset-related, specific functions (helper vs. cytolytic) and differences in major histocompatibility complex-restriction for antigen recognition. However, double positive (DP) T cells expressing both CD4 and CD8 have been described in several pathological conditions as well as in normal individuals. DP T cells represent a heterogeneous population. Strong evidence indicates that in vivo terminally differentiated effector CD4 may acquire the a-chain of CD8. Reciprocally, in vitro activation of CD8+ T cells results in the expression of low levels of CD4 that may mediate HIV entry and responses to chemotactic cytokines. Particularly intriguing, a subset of DP T cells expressing high levels of both CD4 and CD8alphabeta heterodimer (CD4(hi) CD8(hi)), has been identified in autoimmune and chronic inflammatory disorders. While no definitive proof exists, it could be speculated that CD4(hi)CD8(hi) T cells may be endowed with auto-reactivity due to faulty thymic selection. (C) 2003 Elsevier B.V. All rights reserved.