Design Strategies for Fluorescent Biodegradable Polymeric Biomaterials.
Design Strategies for Fluorescent Biodegradable Polymeric Biomaterials.
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荧光生物降解聚合物生物材料的设计策略。
DOI：
10.1039/c2tb00071g
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发表时间：
2013-01-14
期刊：
影响因子：
--
通讯作者：
Yang J
中科院分区：
文献类型：
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作者：
Zhang Y;Yang J
生物可降解聚合物与荧光成像技术的结合，产生了一个重要的生物高分子材料领域：生物可降解荧光聚合物。由于荧光生物材料在生物/生物医学标记、跟踪、监测、成像和诊断应用中的前景，特别是在药物输送、组织工程和癌症成像应用中，研究人员已经投入了大量的精力来开发多功能荧光生物材料。可生物降解的荧光聚合物不仅可以作为植入生物材料，而且可以作为成像探针。目前，有两大类可生物降解的聚合物用作荧光材料。第一类是非荧光生物降解聚合物和荧光剂如有机染料和量子点的组合。另一类聚合物显示出固有的光致发光，其本身在聚合物主链中或悬垂于聚合物主链上携带完整的荧光化学结构，例如绿色荧光蛋白（GFP）和最近开发的可生物降解的光致发光聚合物（BPLP）。因此，对于后者，不需要缀合或包封另外的荧光材料。本文综述了荧光可生物降解聚合物材料的荧光机理、荧光设计准则及其在生物医学工程中的前沿应用。我们期望这篇综述将为荧光生物材料的设计提供有见地的讨论，并为下一代荧光生物材料和基于荧光的生物医学技术的发展带来创新。
The marriage of biodegradable polymer and fluorescent imaging has resulted in an important area of polymeric biomaterials: biodegradable fluorescent polymers. Researchers have put significant efforts on developing versatile fluorescent biomaterials due to their promising in biological/biomedical labeling, tracking, monitoring, imaging, and diagnostic applications, especially in drug delivery, tissue engineering, and cancer imaging applications. Biodegradable fluorescent polymers can function not only as implant biomaterials but also as imaging probes. Currently, there are two major classes of biodegradable polymers used as fluorescent materials. The first class is the combination of non-fluorescent biodegradable polymers and fluorescent agents such as organic dyes and quantum dots. Another class of polymers shows intrinsic photoluminescence as polymers by themselves carrying integral fluorescent chemical structures in or pendent to their polymer backbone, such as Green Fluorescent protein (GFP), and the recently developed biodegradable photoluminescent polymer (BPLP). Thus there is no need to conjugate or encapsulate additional fluorescent materials for the latter. In the present review, we will review the fluorescent biodegradable polymers with emphases on material fluorescence mechanism, design criteria for fluorescence, and their cutting-edge applications in biomedical engineering. We expect that this review will provide insightful discussion on the fluorescent biomaterial design and lead to innovations for the development of the next generation of fluorescent biomaterials and fluorescence-based biomedical technology.