A comparative analysis of Meox1 and Meox2 in the developing somites and limbs of the chick embryo
A comparative analysis of Meox1 and Meox2 in the developing somites and limbs of the chick embryo
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DOI：
10.1387/ijdb.072332sr
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发表时间：
2007-01-01
影响因子：
0.7
通讯作者：
Mankoo, Baljinder S.
中科院分区：
文献类型：
--
作者：
Reijntjes, Susan;Stricker, Sigmar;Mankoo, Baljinder S.
我们已经研究了在早期发展和晚期肢芽阶段的禽Meoxl同源框基因的表达模式。它的表达模式表明它参与体节的特化和分化。表达结构域与Meox 2相似但不同。Meoxl从第6阶段开始在前体节中胚层中表达，并且随着发育的进行，在尾芽、吻体节的皮肌节和尾体节的皮肌节和硬结、外直肌、心脏的动脉干和肢芽中表达。与Meoxl不同，Meox2不在前体节中胚层中表达，而是首先在从第11阶段开始形成的体节中表达。在发育中的肢体，这两个基因表达在背侧和腹侧肢体中胚层在相邻的领域有一个小的重叠区域。在肢芽中，Meox 1与Meox 2共表达，但Meox基因均不与MyoD共表达。这些表达模式表明，这两个基因在发育中有重叠和不同的功能。
We have examined the expression pattern of the avian Meoxl homeobox gene during early development and up to late limb bud stages. Its expression pattern indicates that it is involved in somite specification and differentiation. The domains of expression are similar but different to those of Meox2. Meoxl is expressed from stage 6 in the pre-somitic mesoderm and as development proceeds, in the tail bud, the dermomyotome of the rostral somites and in the dermomyotome and sclerotome of the caudal somites, the lateral rectus muscle, truncus arteriosus of the heart and the limb buds. Unlike Meoxl, Meox2is not expressed in the pre-somitic mesoderm, but is expressed first in somites formed from stage 11 onwards. In the developing limb, both genes are expressed in the dorsal and ventral limb mesoderm in adjacent domains with a small region of overlap. In the limb bud, Meoxl is co-expressed with Meox2 but neither Meox gene is co-expressed with MyoD. These expression patterns suggest that these two genes have overlapping and distinct functions in development.