Decreased neurofilament light chain levels in estriol-treated multiple sclerosis.
Decreased neurofilament light chain levels in estriol-treated multiple sclerosis.
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DOI：
10.1002/acn3.51622
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发表时间：
2022-08
影响因子：
5.3
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中科院分区：
文献类型：
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雌激素在临床前模型以及健康和疾病期间的女性中具有神经保护作用，具体取决于雌激素类型、剂量和时间。血清神经丝轻链是多发性硬化症、衰老和其他神经退行性疾病中神经退行性疾病的假定生物标志物。在这里，使用 8 毫克剂量口服妊娠特有的雌激素（雌三醇）来诱导妊娠中期血液雌三醇水平，降低了平均年龄 37 岁的非妊娠多发性硬化症女性的血清神经丝轻链。这与雌三醇介导的神经轴突损伤保护作用一致，并支持使用血清神经丝轻链作为多发性硬化症的生物标志物。
Estrogens have neuroprotective actions depending on estrogen type, dose, and timing in both preclinical models and in women during health and disease. Serum neurofilament light chain is a putative biomarker of neurodegeneration in multiple sclerosis, aging, and other neurodegenerative diseases. Here, oral treatment with an estrogen unique to pregnancy (estriol) using an 8 mg dose to induce a mid‐pregnancy blood estriol level reduced serum neurofilament light chain in nonpregnant MS women at mean age of 37 years. This is consistent with estriol‐mediated protection from neuro‐axonal injury and supports the use of serum neurofilament light chain as a biomarker in MS.