The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination.
The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination.
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DOI：
10.1158/2159-8290.cd-12-0329
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发表时间：
2012-12
期刊：
影响因子：
28.2
通讯作者：
Hynes RO
中科院分区：
文献类型：
--
作者：
Labelle M;Hynes RO
肿瘤细胞通过血液循环从原发肿瘤转移到远处器官中形成转移。在此过程中，肿瘤细胞会遇到许多环境挑战和刺激，这些挑战和刺激会深刻影响其转移潜力。在这里，我们回顾了合作和动态的宿主-肿瘤细胞相互作用，支持和促进血行播散的癌细胞的远处转移的网站。特别是，我们讨论了什么是已知的肿瘤细胞，血小板，白细胞和内皮细胞之间发生的串扰，以及如何组织这些细胞间的相互作用在时间和空间上的外渗和早期转移的小生境的网站。
Tumor cells transit from the primary tumor via the blood circulation to form metastases in distant organs. During this process, tumor cells encounter a number of environmental challenges and stimuli that profoundly impact their metastatic potential. Here, we review the cooperative and dynamic host-tumor cell interactions that support and promote the hematogenous dissemination of cancer cells to sites of distant metastasis. In particular, we discuss what is known about the crosstalk occurring among tumor cells, platelets, leukocytes and endothelial cells and how these cell-cell interactions are organized both temporally and spatially at sites of extravasation and in the early metastatic niche.