Timing of puberty determines serum insulin-like growth factor-I in late adulthood
Timing of puberty determines serum insulin-like growth factor-I in late adulthood
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DOI：
10.1210/jc.2005-2318
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发表时间：
2006-08-01
影响因子：
5.8
通讯作者：
Ben-Shlomo, Yoav
中科院分区：
文献类型：
--
作者：
Sandhu, Jat;Smith, George Davey;Ben-Shlomo, Yoav
背景：IGF 可能在疾病病因学中发挥重要作用，尤其是癌症。饮食的变化可以改变急性水平，但对于生命历程对 IGF 水平的影响知之甚少。 目的：本研究的目的是检查青春期时间和成年血清 IGF（IGF-I 和 IGF 结合蛋白-3）之间的关联。设计：这是一项回顾性队列研究。背景：研究的一部分是在英格兰南部一所学校就读的男学生。参与者：研究参与者是 1927 年至 1956 年出生的 1028 名男性，在 9 至 18 岁之间进行人体测量，并测量成年血清 IGF 水平。主要结果测量：该研究测量了血清 IGF-I 和 IGF 结合 平均年龄 63 岁的 Protein-3 结果：峰值高度速度 (APHV) 年龄与成人 IGF-I 水平呈负相关。 APHV 每增加一个 SD，IGF-I 就会减少 3.7 ng/ml（95% 置信区间 1.0-6.4，P = 0.007）。青春期前儿童身高和体重指数均与 APHV 呈负相关（P 趋势 < 0.001）。 APHV 与成人身高呈正相关，与成人体重指数呈负相关。对童年、成人人体测量和其他生活方式因素进行调整并没有显着改变 APHV 与成人 IGF-I 之间的关联。结论：这是第一项记录青春期时间与成人 IGF-I 水平之间关联的研究。更好地了解 IGF 系统的生命历程决定因素可能会为疾病病因学和一级预防提供新的见解。
Context: IGFs may play an important role in disease etiology, especially cancer. Changes in diet can alter acute levels, but little is known about life course influences on IGF levels.Objective: The objective of the study was to examine the association between timing of puberty and adulthood serum IGFs (IGF-I and IGF binding protein-3). Design: This was a retrospective cohort study.Setting: Male pupils who attended a single school in Southern England were part of the study.Participants: Participants in the study were a cohort of 1028 men born between 1927 and 1956 with anthropometric measures between 9 and 18 yr and adulthood serum IGF levels.Main Outcome Measure: The study measured serum IGF-I and IGF binding protein-3 at mean age 63 yr.Results: Age at peak height velocity (APHV) was inversely associated with adult IGF-I levels. IGF-I decreased by 3.7 ng/ml (95% confidence interval 1.0-6.4, P = 0.007) for each SD increase in APHV. Prepubertal childhood height and body mass index were both inversely associated with APHV (P trend < 0.001). APHV was positively associated with adult height and inversely associated with adult body mass index. Adjustment for childhood, adult anthropometry, and other lifestyle factors did not substantially alter the association between APHV and adult IGF-I.Conclusions: This is the first study to document an association between timing of puberty and adult IGF-I levels. A better understanding of life course determinants of the IGF system may provide new insights into disease etiology and primary prevention.