MODELS FOR SPECIFIC ADHESION OF CELLS TO CELLS
MODELS FOR SPECIFIC ADHESION OF CELLS TO CELLS
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DOI：
10.1126/science.347575
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
BELL, GI
中科院分区：
文献类型：
--
作者：
BELL, GI
提出了一种分析细胞间或细胞与表面的黏附的理论框架，这种黏附是由特定分子如抗原和抗体、凝集素和碳水化合物或酶和底物之间的可逆键介导的。根据反应物在溶液中的反应速率及其在溶液和膜上的扩散常数的知识，可以估计膜结合的反应物的反应速率。建立了两个预测细胞间成键速率的模型，并与实验进行了比较。分离两个细胞所需的力大于细胞间的预期电动力，与将神经节苷脂和一些完整的膜蛋白从细胞膜中拉出所需的力相同数量级。
A theoretical framework is proposed for the analysis of adhesion between cells or of cells to surfaces when the adhesion is mediated by reversible bonds between specific molecules such as antigen and antibody, lectin and carbohydrate or enzyme and substrate. From a knowledge of the reaction rates for reactants in solution and of their diffusion constants both in solution and on membranes, it is possible to estimate reaction rates for membrane-bound reactants. Two models are developed for predicting the rate of bond formation between cells and are compared with experiments. The force required to separate 2 cells is greater than the expected electrical forces between cells, and of the same order of magnitude as the forces required to pull gangliosides and perhaps some integral membrane proteins out of the cell membrane.