Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study
Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study
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DOI：
10.1111/joim.12052
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发表时间：
2013-07-01
影响因子：
11.1
通讯作者：
de Craen, A. J. M.
中科院分区：
文献类型：
--
作者：
Mooijaart, S. P.;Sattar, N.;de Craen, A. J. M.
Background Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The objective of this study was to investigate the associations between both high concentration of IL-6 and the -174 promoter polymorphism, and increased cognitive decline in old age. Methods Over 5000 participants of the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) with a mean age of 75years and a history of cardiovascular disease or its risk factors were included in this study. We determined baseline concentrations of IL-6 and genotype of the IL-6 -174 polymorphism, of which the C allele was previously shown to be associated with higher circulating concentrations of IL-6. A cognitive test battery was administered at baseline and repeatedly during follow-up (mean 39months). Results In the cross-sectional analysis of 5653 participants, higher IL-6 concentration was associated with worse executive cognitive function (P
