Clinical and electroretinographic findings in fetal alcohol syndrome
Clinical and electroretinographic findings in fetal alcohol syndrome
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DOI：
10.1067/mpa.2000.105278
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发表时间：
2000-08-01
期刊：
影响因子：
1.6
通讯作者：
Cibis, GW
中科院分区：
文献类型：
--
作者：
Hug, TE;Fitzgerald, KM;Cibis, GW
目的：胎儿暴露于酒精是一个严重的公共卫生问题，并与眼底异常，以及神经发育迟缓，生长迟缓，面部特征。本文旨在报道胎儿酒精综合征患儿视网膜电图异常的发生率，提高眼科对胎儿酒精综合征诊断的认识。方法：对11例胎儿酒精综合征患儿的临床资料进行回顾性分析。报告了眼科检查、磁共振成像、视力检查和视网膜电图的结果。结果：所有受试者的磁共振成像结果均异常。眼科检查显示91%的受试者视神经发育不良。除1例受试者外，所有受试者的视力均降低。ERG结果异常，显示b波振幅降低、a波和b波隐式时间增加、Rmax降低和log（k）增加。暗视ERG比明视ERG受到更严重的影响。结论：产前酒精暴露可导致视网膜功能的变化，如异常的ERG反应所证明的。因此，视网膜电图可以作为一种工具，以确定可疑的酒精胚胎病。
Purpose: Fetal exposure to alcohol is a serious public health problem and is associated with anomalies of the eye ground, as well as neurodevelopmental delay, growth delay, and characteristic facial features. Our purpose is to report the incidence of abnormal electroretinogram (ERG) results in children with fetal alcohol syndrome and raise awareness of the diagnosis of fetal alcohol syndrome in ophthalmology. Methods: A retrospective review was performed on the records of 11 children with the diagnosis of fetal alcohol syndrome. The results of the ophthalmologic examination, magnetic resonance imaging, visual acuity test, and ERG are reported. Results: The magnetic resonance imaging results were abnormal in all subjects tested. The ophthalmology examination showed optic nerve hypoplasia in 91% of the subjects. Visual acuity was reduced in all but one subject. The ERG results were abnormal, showing reduced b-wave amplitude, increased a- and b-wave implicit time, reduced Rmax, and increased log (k). The scotopic ERG was more severely affected than the photopic ERG. Conclusions: Prenatal alcohol exposure can lead to changes in retinal function as evidenced by an abnormal ERG response. The ERG can therefore be a tool with which to identify suspected alcohol embryopathy.