The Ca(2+) -activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis.
The Ca(2+) -activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis.
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DOI：
10.1002/cam4.232
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发表时间：
2014-06
期刊：
影响因子：
4
通讯作者：
Hartzell, Criss
中科院分区：
文献类型：
--
作者：
Qu, Zhiqiang;Yao, Weicheng;Yao, Ruyong;Liu, Xiangping;Yu, Kuai;Hartzell, Criss
由于anoctamin 1ano1 （TMEM16A）被发现是Ca2+激活的Cl -通道的分子组分，其在肿瘤发生中的作用得到了迅速的关注。ANO1过表达常发生在癌组织中，并伴有11q13染色体扩增。许多类型癌症的预后不良与ANO1基因扩增和蛋白过表达密切相关。ANO1现在被认为是某些癌症的优秀生物标志物。最近的研究表明ANO1的通道功能参与了肿瘤的发生。然而，功能性ANO1的过表达如何通过信号通路（如MAPK）引起组织的恶性转化仍有待研究。今后对其原因的澄清将有助于使ANO1成为癌症治疗的靶点。
Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca2+-activated Cl− channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment.
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