A large outbreak of Legionnaires' disease at a flower show, the Netherlands, 1999
A large outbreak of Legionnaires' disease at a flower show, the Netherlands, 1999
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DOI：
10.3201/eid0801.010176
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发表时间：
2002-01-01
影响因子：
11.8
通讯作者：
Conyn-Van Spaendonck, MAE
中科院分区：
文献类型：
--
作者：
Den Boer, JW;Yzerman, EPF;Conyn-Van Spaendonck, MAE
1999年，在荷兰的一个花展上，军团病的爆发影响了许多参观者。为了确定爆发的来源，我们进行了环境调查，以及在参观者中进行的病例对照研究和在参展商中进行的血清学队列研究，以测量对可能来源的暴露。在77，061名参观者中，188人患病（133例确诊病例和55例可能病例），参观者和参展商的发病率分别为0.23%和0.61%。展览馆3号和4号厅的两个漩涡水疗中心和8号厅的一个喷水器对嗜肺军团菌培养呈阳性。在两个漩涡温泉中发现的三种基因型之一与29名培养阳性患者中的28名的分离株相同。在3号大厅的漩涡水疗中心停留的人生病的风险增加。这项研究表明，漩涡水疗中心可能是一个重要的健康危害，如果消毒失败。
In 1999, an outbreak of Legionnaires' disease affected many visitors to a flower show in the Netherlands. To identify the source of the outbreak, we performed an environmental investigation, as well as a case-control study among visitors and a serologic cohort study among exhibitors to measure exposure to possible sources. Of 77,061 visitors, 188 became ill (133 confirmed and 55 probable cases), for an attack rate of 0.23% for visitors and 0.61% for exhibitors. Two whirlpool spas in halls 3 and 4 of the exhibition and a sprinkler in hall 8 were culture positive for Legionella pneumophila. One of three genotypes found in both whirlpool spas was identical to the isolates from 28 of 29 culture-positive patients. Persons who paused at the whirlpool spa in hall 3 were at increased risk for becoming ill. This study illustrates that whirlpool spas may be an important health hazard if disinfection fails.