Animal models of calcific aortic valve disease.
Animal models of calcific aortic valve disease.
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DOI：
10.4061/2011/364310
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发表时间：
2011
影响因子：
2
通讯作者：
Simmons CA
中科院分区：
文献类型：
--
作者：
Sider KL;Blaser MC;Simmons CA
钙化性主动脉瓣疾病（CAVD），曾经被认为是一种退行性疾病，现在被认为是一种活跃的病理生物学过程，慢性炎症是一种主要的，可能是驱动因素。然而，CAVD的病理生物学机制的许多细节仍有待描述，需要确定治疗CAVD的新方法。动物模型正在成为实现这一目标的重要工具，这得益于新模型的出现和对现有模型效用的更好理解。本文对目前CAVD的小型和大型动物模型进行了总结和评价，讨论了CAVD动物模型在优先研究领域的应用，并对未来CAVD动物模型研究提出了建议。
Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be described, and new approaches to treat CAVD need to be identified. Animal models are emerging as vital tools to this end, facilitated by the advent of new models and improved understanding of the utility of existing models. In this paper, we summarize and critically appraise current small and large animal models of CAVD, discuss the utility of animal models for priority CAVD research areas, and provide recommendations for future animal model studies of CAVD.