Pattern of P50 suppression deficit in patients with epilepsy and individuals with schizophrenia
Pattern of P50 suppression deficit in patients with epilepsy and individuals with schizophrenia
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DOI：
10.1590/s0004-282x2011000400010
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发表时间：
2011-06-01
影响因子：
1.4
通讯作者：
Costa, Jaderson Costa da
中科院分区：
文献类型：
--
作者：
Becker, Jefferson;Filho, Irenio Gomes da Silva;Costa, Jaderson Costa da
目的：研究癫痫患者的P50抑制，探讨癫痫发作控制对P50抑制的影响，并将癫痫患者与精神分裂症患者和健康志愿者进行比较。方法：在未控制或控制癫痫患者、精神分裂症患者和健康志愿者中，对P50诱发电位参数和P50抑制进行了横断面研究。结果如下：精神分裂症患者的条件刺激（Si）幅度明显较小，癫痫患者的测试刺激（S2）幅度较大。未控制癫痫患者的平均S2/S1比值为0.71+/-0.33;控制癫痫患者为0.68+/-0.36;精神分裂症患者为0.96+/-0.47;健康志愿者为0.42+/-0.24。结论：癫痫患者的感觉过滤功能发生改变，这种改变与癫痫发作控制无关。此外，它的工作原理与精神分裂症患者的感官过滤器不同。
Objective: To identify P50 suppression in patients with epilepsy, to investigate the effect of seizure control on P50 suppression, and to compare epilepsy patients with individuals with schizophrenia and healthy volunteers. Method: P50 evoked potential parameters and P50 suppression were studied crossectionally in patients with uncontrolled or controlled epilepsy, in individuals with schizophrenia and in healthy volunteers. Results: Individuals with schizophrenia had significantly smaller conditioning stimulus (Si) amplitude, and patients with epilepsy had larger test stimulus (S2) amplitude. Mean S2/S1 ratio was 0.71+/-0.33 for patients with uncontrolled epilepsy; 0.68+/-0.36 for patients with controlled epilepsy; 0.96+/-0.47 for individuals with schizophrenia, and 0.42+/-0.24 for healthy volunteers. Conclusion: The sensory filter of patients with epilepsy is altered, and this alteration is not associated with seizure control. Also, it works differently from the sensory filter of individuals with schizophrenia.