Disorganization of anatomical connectivity in obsessive compulsive disorder: A multi-parameter diffusion tensor imaging study in a subpopulation of patients
Disorganization of anatomical connectivity in obsessive compulsive disorder: A multi-parameter diffusion tensor imaging study in a subpopulation of patients
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DOI：
10.1016/j.nbd.2009.11.003
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发表时间：
2010-02-01
影响因子：
6.1
通讯作者：
Perani, D.
中科院分区：
文献类型：
--
作者：
Garibotto, V.;Scifo, P.;Perani, D.
强迫症（obsessive-compulsive disorder，OCD）被认为涉及大规模的脑系统，但通过关联纤维的解剖连接尚未被专门研究。我们通过测量与水自扩散相关的MRI参数，评估了强迫症亚群中主要纤维束的组织和方向性，包括表现出决策缺陷的垫圈和跳棋强迫症患者双侧胼胝体、扣带回、上级纵束、额枕下束的FA值明显降低，PDD值沿着改变。对下额枕束的基于轨迹的分析证实了双侧FA显著减少。额枕下束、上级纵束和胼胝体的FA值较低，与症状严重程度和神经心理学表现相关。多参数MRI研究显示，强迫症患者存在特定的白色物质异常，提示以神经束紊乱为主要特征，反映为纤维方向性的局部变化。这种改变的解剖连接可能在强迫症的病理生理学中发挥特定的作用。(C)2009 Elsevier Inc. All rights reserved.
obsessive-compulsive disorder (OCD) is thought to involve large-scale brain systems but the anatomical connectivity via association fibers has not been specifically investigated yet.We evaluated organization and directionality of the major fiber bundles in a subpopulation of OCD, including washers and checkers who presented decision making deficits, by measuring MRI parameters related to water self-diffusion (Fractional Anisotropy, FA) and fiber directionality (Principal Diffusion Direction, PDD) in 15 OCD and 16 control subjects.OCD patients showed significantly lower FA and altered PDD along the corpus callosum, cingulum, superior longitudinal fasciculus, and inferior fronto-occipital fasciculus bilaterally. The track-based analysis of the inferior fronto-occipital fasciculus confirmed a significant bilateral FA reduction. Lower FA values in the inferior fronto-occipital fasciculus, superior longitudinal fasciculus and corpus callosum correlated with symptom severity and neuropsychological performance.This multi-parameter MRI study revealed specific white matter abnormalities in OCD suggesting tract disorganization as main feature, reflected by local changes in fiber directionality. This altered anatomical connectivity might play a specific role in OCD pathophysiology. (C) 2009 Elsevier Inc. All rights reserved.