THE PERSISTENCE OF THE EFFICACY OF INJECTABLE OR ORAL MOXIDECTIN AGAINST TELADORSAGIA, HAEMONCHUS AND TRICHOSTRONGYLUS SPECIES IN EXPERIMENTALLY INFECTED SHEEP
THE PERSISTENCE OF THE EFFICACY OF INJECTABLE OR ORAL MOXIDECTIN AGAINST TELADORSAGIA, HAEMONCHUS AND TRICHOSTRONGYLUS SPECIES IN EXPERIMENTALLY INFECTED SHEEP
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DOI：
10.1136/vr.137.16.399
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发表时间：
1995-10-14
影响因子：
2.2
通讯作者：
BLONDRIOU, F
中科院分区：
文献类型：
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作者：
KERBOEUF, D;HUBERT, J;BLONDRIOU, F
将55只羔羊随机分为11个相同的组，在第0天感染莫西菌素，评估莫西菌素1%注射溶液对实验胃肠道线虫感染的持续有效性。在第42、第35、第28、第21和第14天，其中5组以0.2 mg莫西菌素/kg体重的剂量率给予莫西菌素1%注射溶液；另外5组分别于第35、28、21、14、7天以相同剂量率口服莫西菌素0.1%滴注，第11组不作对照。实验羔羊分别感染包皮端足虫8000只、弯血螨2000只、色毛滴虫10000只，3周后处死。莫西菌素的两种制剂对环切T虫和弯曲H虫均表现出良好的活性，在治疗后35天内对可憎寄生虫的治疗效果几乎为100%。莫西菌素1%注射对结肠T虫的治疗效果远高于口服淋剂（约99%），在治疗后21天内非常有效，并在治疗后35天内适度减少蠕虫负担。所有动物未见莫西丁不良反应。
The persistence of the efficacy of moxidectin was evaluated against experimental gastrointestinal nematode infections in 55 lambs randomly allocated to 11 equal groups and infected on day 0, Moxidectin 1 per cent injectable solution was administered at a dose rate of 0.2 mg moxidectin/kg bodyweight to five of the groups on days -42, -35, -28, -21 and -14; five other groups were treated with moxidectin 0 1 per cent oral drench at the same dose rate on days -35, -28, -21, -14 and -7, and the 11th group remained untreated as a control, The lambs were infected experimentally with 8000 Teladorsagia circumcincta, 2000 Haemonchus contortus and 10,000 Trichostrongylus colubriformis infective larvae and killed three weeks later, Both formulations of moxidectin showed excellent activity against T circumcincta and H contortus with almost 100 per cent efficacy against the abomasal parasites for up to 35 days after treatment, The efficacy of moxidectin 1 per cent injectable against T colubriformis was much higher (>99 per cent) than that of the oral drench and it was highly effective up to 21 days after treatment, and gave a moderate reduction in worm burden for up to 35 days after treatment, No adverse reactions to moxidectin were observed in any of the animals.