Peptidoglycan recognition in Drosophila
Peptidoglycan recognition in Drosophila
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DOI：
10.1042/bst0351496
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发表时间：
2007-12-01
影响因子：
3.9
通讯作者：
Silverman, N.
中科院分区：
文献类型：
--
作者：
Aggrawal, K.;Silverman, N.
果蝇主要依靠先天免疫反应来有效地对抗各种微生物病原体。果蝇体液免疫反应的标志是脂肪体快速产生AMPS（抗菌肽），脂肪体是哺乳动物肝脏的昆虫同源物。这些AMP的产生在转录水平上由两个NF-κ B（核因子κ B）信号传导途径控制。Toll途径由真菌和许多革兰氏阳性细菌微生物激活，而IMD（免疫缺陷）途径响应革兰氏阴性细菌和某些革兰氏阳性杆菌。本文综述了细菌识别的机制，特别是PGRP（PGN recognition protein，PGN识别蛋白）受体家族的不同成员对不同类型细菌PGN（peptidoglycan，肽聚糖）的不同识别。
Drosophila rely primarily on innate immune responses to effectively combat a wide array of microbial pathogens. The hallmark of the Drosophila humoral immune response is the rapid production of AMPS (antimicrobial peptides) by the fat body, the insect homologue of the mammalian liver. Production of these AMPs is controlled at the level of transcription by two NF-kappa B (nuclear factor kappa B) signalling pathways. The Toll pathway is activated by fungal and many Gram-positive bacterial microbes, whereas the IMD (immune deficiency) pathway responds to Gram-negative bacteria and certain Gram-positive bacilli. in the present review, we discuss the mechanisms involved in bacterial recognition, in particular the differential recognition of various types of bacterial PGN (peptidoglycan) by different members of the PGRP (PGN recognition protein) family of receptors.