Electron paramagnetic resonance oxygen imaging in vivo
Electron paramagnetic resonance oxygen imaging in vivo
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DOI：
10.1039/9781849734837-00180
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Halpern, Howard
中科院分区：
文献类型：
--
作者：
Epel, Boris;Halpern, Howard
本综述涵盖了 EPR 体内氧成像过去 15 年的发展。在此期间，发生了许多重大技术和方法的进步。窄线宽、长弛豫时间和无毒的三芳基甲基自由基于 20 世纪 90 年代末推出。这些不仅改进了连续波 (CW) 成像，而且使脉冲 EPR 成像在动物身上的应用成为可能。脉冲技术的最新发展使图像采集速度提高了一个数量级，灵敏度增强，并且氧测量的精度和准确度显着提高。因此，脉冲方法占据了本次综述的重要部分。
This review covers the last 15 years of the development of EPR in vivo oxygen imaging. During this time, a number of major technological and methodological advances have taken place. Narrow line width, long relaxation time, and non-toxic triaryl methyl radicals were introduced in the late 1990s. These not only improved continuous wave (CW) imaging, but also enabled the application of pulse EPR imaging to animals. Recent developments in pulse technology have brought an order of magnitude increase in image acquisition speed, enhancement of sensitivity, and considerable improvement in the precision and accuracy of oxygen measurements. Consequently, pulse methods take up a significant part of this review.