DEVELOPMENT OF DROSOPHILA RETINA, A NEUROCRYSTALLINE LATTICE
DEVELOPMENT OF DROSOPHILA RETINA, A NEUROCRYSTALLINE LATTICE
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DOI：
10.1016/0012-1606(76)90225-6
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发表时间：
1976-01-01
影响因子：
2.7
通讯作者：
BENZER, S
中科院分区：
文献类型：
--
作者：
READY, DF;HANSON, TE;BENZER, S
果蝇视网膜中的图案形成是通过细胞的募集来进行的，沿着形态发生前沿，形成网格。在由眼睛的背腹侧沟标记的前方，细胞组织成小眼前体，每个小眼前体包含注定成为光感受器2、3、4、5和8的细胞。在前面后面，有丝分裂波产生光感受器1，6和7，加上完成小眼所需的剩余细胞。在第三龄幼虫，前扫向前跨越眼盘，留下一个高度有序的模式在其尾迹。在背腹沟之前是一个将眼盘分为背侧和腹侧两半的沟，并且可能在建立赤道对称线中起作用。细胞谱系在眼睛的图案形成中几乎没有作用。遗传镶嵌显示，每个小眼的细胞不是来自一个单一的母细胞;细胞似乎是随机招募的形态发生前沿。同样，赤道上下的镜像对称性也不是由克隆机制建立的;单个克隆可以为赤道两侧的小眼提供细胞。
Pattern formation in the Drosophila retina proceeds by the recruitment of cells, along a morphogenetic front, into a lattice. At the advancing front marked by a dorso-ventral furrow in the eye imaginal disk, cells organize into ommatidial precursors, each containing cells destined to become photoreceptors 2, 3, 4, 5, and 8. Behind the front, a mitotic wave produces photoreceptors 1, 6 and 7, plus the remaining cells needed to complete the ommatidia. During the 3rd larval instar, the front sweeps anteriorly across the eye disk, leaving a highly ordered pattern in its wake. Preceding the dorso-ventral furrow is a groove that bisects the eye disk into dorsal and ventral halves and presumably plays a role in establishing the equatorial symmetry line. Cell lineage plays little role in pattern formation in the eye. Genetic mosaics show that the cells of each ommatidium are not derived from a single mother cell; the cells appear to be recruited at random at the morphogenetic front. Similarly, the mirror symmetry above and below the equator is not established by a clonal mechanism; a single clone can contribute cells to ommatidia on both sides of the equator.