The IGF family and folliculogenesis
The IGF family and folliculogenesis
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DOI：
10.1016/s0165-0378(98)00026-6
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发表时间：
1998-08-01
影响因子：
3.4
通讯作者：
Adashi, EY
中科院分区：
文献类型：
--
作者：
Adashi, EY
卵巢卵泡的发育是一个漫长而艰巨的过程，其特征是体细胞和生殖细胞成分的急剧增殖和分化。在很大程度上，这种爆炸性的议程是在传统的内分泌原则的控制下，涉及激素，如垂体促性腺激素和卵巢类固醇。重要的是，它已经变得越来越明显，几个现象的核心卵巢生理学是不完全占传统的内分泌原则。作为一个例子，必须考虑到卵泡选择的过程，即预定数量的卵泡被招募，选择，允许断言优势？并最终排卵，尽管事实上所有的卵泡都被提供了相当的促性腺激素刺激。这些观察结果表明，卵巢功能的调节可能受到另一组调节原则的控制，这些调节原则被称为“推定的卵巢内调节因子”。一般认为，这些局部衍生的肽能原理的精确定时和高度区域化的表达可能最终解释了卵巢生命周期的那些方面，而这些方面在这个时候违背了传统的解释。据推测，IGF-1在卵巢生理学中的作用是作为促性腺激素激素作用的放大器。此时，可以记录对该假设的重要支持。更推测的是IGF-I可能参与卵泡内室间协调的概念，这一概念预先假定由于颗粒-卵泡膜-间质细胞的串扰和改善的偶联而增强了更协调的卵泡发育。在推测领域中，有一种观点认为IGF-1可能实际上参与了卵泡选择的过程，这一观点目前得到的支持相对有限。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
The process of ovarian follicular development is a long and arduous one, marked by dramatic proliferation and differentiation of both the somatic and germ cell elements. To a large extent, this explosive agenda is under the control of conventional endocrine principles, involving hormones such as pituitary gonadotropins and ovarian steroids. Importantly, it has become increasingly apparent that several phenomena central to ovarian physiology are not fully accounted for by conventional endocrine principles. As an example, consideration must be given to the process of follicular selection whereby a predetennined number of follicle(s) is recruited, selected, allowed to assert dominance? and ultimately ovulate despite the fact that all follicles are afforded comparable gonadotropic stimulation. These observations have given rise to the suggestion that the regulation of ovarian function may be under the control of yet another group of modulatory principles known under the general term 'putative intra-ovarian regulators'. It is generally envisioned that the exquisitely-timed and highly-regionalized expression of these locally-derived, often peptidergic, principles may finally account for those aspects of the ovarian life cycle which at this time defy conventional explanation. It has been hypothesized that the role of IGF-1 in the context of ovarian physiology is to serve as an amplifier of gonadotropin hormonal action. At this time, significant support for this hypothesis can be documented. More speculative is the notion that IGF-I may partake in intrafollicular intercompartmental coordination, a concept presupposing enhanced more coordinated follicular development, due to granulosa-theca-interstitial cell cross-talk and improved coupling. Entirely in the speculative realm is the proposition that IGF-1 may in fact partake in the process of follicular selection, a notion for which relatively limited support can be: derived at this time. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.