Glycosaminoglycans (GAGs) and GAG mimetics regulate the behavior of stem cell differentiation
Glycosaminoglycans (GAGs) and GAG mimetics regulate the behavior of stem cell differentiation
复制标题
糖胺聚糖 (GAG) 和 GAG 模拟物调节干细胞分化的行为
DOI：
10.1016/j.colsurfb.2016.11.022
复制
发表时间：
2017-02-01
影响因子：
5.8
通讯作者：
Chen, Hong
中科院分区：
文献类型：
--
作者：
Wang, Mengmeng;Liu, Xiaoli;Chen, Hong
糖胺聚糖（GAG）是存在于大多数哺乳动物细胞中的线性硫酸化多糖。通过与各种蛋白质结合，GAG在各种生物活性中发挥重要作用，包括促进干细胞分化。然而，它们也有其固有的缺点，限制了它们在细胞治疗和组织工程中的进一步应用。因此，越来越多的GAG模拟物材料作为天然GAG类似物被研究用于新兴应用。本文阐述了糖胺聚糖调节干细胞分化的机制，并阐述了糖胺聚糖类材料在调节干细胞分化方面的应用进展。介绍了GAG模拟物的种类及其在干细胞分化调控中的应用。最后，糖胺聚糖及其模拟物在调节干细胞分化的挑战和前景进行了讨论。(C)© 2016 Elsevier B.V.版权所有。
Glycosaminoglycans (GAGs) are linear sulfated polysaccharides that exist in most mammalian cells. By undergoing conjugation with various proteins, GAGs play important roles in a variety of bioactivities, including promoting stem cell differentiation. However, they have their own intrinsic disadvantages that limit their further applications for cell therapy and tissue engineering. Therefore, more and more GAG-mimetic materials have been studied as natural GAG analogs for emerging applications. This review explains the mechanism of how GAGs regulate stem cell differentiation and elaborates on the current progress of the applications of GAG-based materials on regulating stem cell differentiation. The types and applications of GAG-mimetic materials on regulating stem cell differentiation are introduced as well. Finally, the challenges and perspectives for GAGs and their mimetics in regulating stem cell differentiation are discussed. (C) 2016 Elsevier B.V. All rights reserved.