The interaction of thyroxine with plasma proteins: localization of thyroxine-binding protein in Cohn fractions of plasma.
The interaction of thyroxine with plasma proteins: localization of thyroxine-binding protein in Cohn fractions of plasma.
复制标题
甲状腺素与血浆蛋白的相互作用：血浆科恩级分中甲状腺素结合蛋白的定位。
DOI：
10.1172/jci103223
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发表时间：
1955
期刊：
影响因子：
--
通讯作者：
S. Ingbar
中科院分区：
文献类型：
--
作者：
N. Freinkel;J. Dowling;S. Ingbar
最近，区域电泳技术已被用来表征血浆中甲状腺素结合的部位（1-7）。在大多数报告中，甲状腺素与pH 8.6时α -球蛋白和α -球蛋白之间电泳迁移的中间蛋白片段之间存在关联。这种甲状腺素结合蛋白（TBP）的浓缩来源尚未用于进一步纯化或对其生理作用的实验评估。为了实现这些目标，区域电泳技术被用于定位Cohn和他的同事用方法6制备的血浆亚组分中的TBP（8,9）。
Recently zone electrophoretic techniques have been employed to characterize the site of thyroxine-binding in plasma (1-7). In most reports, an association has been described between thyroxine and a protein moiety intermediate in electrophoretic mobility at pH 8.6 between the al and the a, globulins. A concentrated source of this thyroxine-binding protein (TBP) has not been available for further purification or for experimental evaluation of its physiological role. To meet these objectives, zone electrophoretic techniques have been employed to localize TBP in subfractions of plasma prepared by Method 6 of Cohn and his co-workers (8, 9).