Gossypol--a new antifertility agent for males.
Gossypol--a new antifertility agent for males.
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棉酚——一种新型男性抗生育剂。
DOI：
10.1159/000299937
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发表时间：
1979
影响因子：
2.1
通讯作者：
A. Gertler
中科院分区：
文献类型：
--
作者：
B. Lindberg;H. Morishita;T. Hashimoto;H. Mitani;T. Tanaka;K. Higuchi;T. Ozasa;M. Pavelka;R. Pavelka;G. Gerstner;H. Feijen;J. Haan;C. Martin;J. Nederstigt;P. Houx;R. Borenstein;D. Rozenman;M. Lancet;Y. Bar;N. Cohen;A. Gertler
棉酚能抑制雄性大鼠的生育能力。使用棉酚后，精子细胞首先受损。随着剂量的增加和治疗时间的延长，精母细胞也受到损伤。附睾中有脱落的精子和精母细胞，其中有许多死亡的精子，其中许多有头部和失败分离。精子数量逐渐减少，直至无精子症。电镜检查显示顶体和线粒体螺旋鞘的改变。睾丸间质细胞似乎未受影响。超过4000名健康男性服用棉酚已超过6个月。精液检查的抗生育效果为99.89%。副作用轻微，发生率低。少数受试者发现低钾血症。然而，棉酚是否与低钾血症的发生有关仍有待阐明。
Gossypol is capable of inhibiting the fertility of male rats. On administration of gossypol the spermatids are damaged first. With the increase in dosage and duration of treatment the spermatocytes are also damaged. In the epidymis there are exfoliated spermatids and spermatocytes with numerous dead spermatozoa many of which had their heads and fails separated. The sperm count gradually decreases until azoospermia. Electron microscopic examinations reveal changes in the acrosomes and mitochondrial spiral sheath. Interstitial cells of the testis seemed to be unaffected. Over 4,000 healthy men have been on gossypol for more than 6 months. The antifertility efficacy evaluated by semen examination is 99.89%. Side effects are mild and of low incidence. A few of the subjects are found to be hypokalemic. However, it remains to be elucidated if gossypol is related to the development of hypokalemia.