EFFECTS OF PHENOL COMPOUNDS, GLUTATHIONE ANALOGS AND A DIURETIC DRUG ON GLUTATHIONE-S-TRANSFERASE, GLUTATHIONE-REDUCTASE AND GLUTATHIONE-PEROXIDASE FROM CANINE ERYTHROCYTES
EFFECTS OF PHENOL COMPOUNDS, GLUTATHIONE ANALOGS AND A DIURETIC DRUG ON GLUTATHIONE-S-TRANSFERASE, GLUTATHIONE-REDUCTASE AND GLUTATHIONE-PEROXIDASE FROM CANINE ERYTHROCYTES
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DOI：
10.1016/0305-0491(92)90206-7
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发表时间：
1992-12-01
影响因子：
2.2
通讯作者：
TAKEDA, K
中科院分区：
文献类型：
--
作者：
KURATA, M;SUZUKI, M;TAKEDA, K
1.比较了酚类化合物（鞣花酸、槲皮素和紫没食子酸）、谷胱甘肽类似物（S-己基谷胱甘肽和S-辛基谷胱甘肽）和利尿剂（依他尼酸）对犬红细胞谷胱甘肽S-转移酶（GST）、谷胱甘肽还原酶（GR）和谷胱甘肽过氧化物酶（GSH-Px）的抑制作用.所有这些化合物都抑制GST活性;槲皮素被发现是最有效的抑制剂。3.鞣花酸、紫没食子酸、槲皮素和依他尼酸抑制GR活性，S-己基谷胱甘肽和S-辛基谷胱甘肽对GR和GSH-Px活性无影响.槲皮素和purpurogallin抑制GST对谷胱甘肽的非竞争性，而鞣花酸表现出竞争性抑制。鞣花酸和purpurogallin抑制GR非竞争性氧化型谷胱甘肽。
1. Phenol compounds (ellagic acid, quercetin and purpurogallin), glutathione analogues (S-hexylglutathione and S-octylglutathione) and a diuretic drug (ethacrynic acid) were compared for their inhibitory effects on glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) in the canine erythrocytes.2. All these compounds inhibited GST activity; quercetin was found to be the most potent inhibitor.3. Ellagic acid, purpurogallin, quercetin and ethacrynic acid inhibited GR activity; S-hexylglutathione and S-octylglutathione had no effect on GR and GSH-Px activities.4. Quercetin and purpurogallin inhibited GST non-competitively toward glutathione, whereas ellagic acid showed a competitive inhibition. Ellagic acid and purpurogallin inhibited GR non-competitively toward oxidized glutathione.