Age, body mass index and Type 2 diabetes - associations modified by ethnicity
Age, body mass index and Type 2 diabetes - associations modified by ethnicity
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DOI：
10.1007/s00125-003-1158-9
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发表时间：
2003-08-01
期刊：
影响因子：
8.2
通讯作者：
Nakagami, T
中科院分区：
文献类型：
--
作者：
Nakagami, T
目标/假设。本研究的目的是评估种族对年龄与体重指数之间的关系以及糖尿病患病率的影响。我们选择了1980年后在DECODE/A研究中进行的基于人群的研究，这些研究代表了不同的种族群体：11个欧洲人，1个马耳他人，3个印度人，2个中国人和3个日本人调查。受试者总数为14,240名男性和15,129名女性，年龄在30岁到89岁之间。糖尿病的诊断是根据1999年世界卫生组织的标准，基于75g口服葡萄糖耐量试验。按年龄和BMI划分的糖尿病性别患病率按种族分组，特别是种族对年龄/BMI和糖尿病患病率之间的关系的交互作用。在印度和马耳他的研究中，与日本、中国和欧洲其他国家相比，糖尿病的患病率更高。对年龄进行调整后，BMI与糖尿病之间的关联显示出明显的种族差异，马耳他和印度人群的患病率从15到20 kg/m(2)开始增加，而欧洲人的BMI/m(2)为25 kg/m(2)。体重指数对年龄调整后的2型糖尿病患病率的影响受到种族的影响，与欧洲其他地区的受试者相比，印度和马耳他受试者的阈值要低得多。这种差异应反映在关于“最佳”BMI的国家和国际建议中。
Aims/hypothesis. The aim of this study was to assess the effect of ethnicity on the association between age and body mass index as well as the prevalence of diabetes.Methods. We selected population-based studies carried out after 1980 in the DECODE/A studies representing different ethnic groups: 11 European, 1 Maltese, 3 Indian, 2 Chinese and 3 Japanese surveys. The total numbers of subjects were 14,240 men and 15,129 women who were 30 to 89 years of age. Diabetes was diagnosed according to the 1999 World Health Organization criteria based on a standard 75 g OGTT. Sex-specific prevalence of diabetes by age and BMI was stratified by ethnic group, in particular the interaction of ethnicity on the associations between age/BMI and the prevalence of diabetes.Results. The prevalence of diabetes was higher in studies from India and Malta compared to Japan, China, and the rest of Europe. The association between BMI and diabetes, adjusted for age, showed noticeable differences between the ethnic groups with an increase in prevalence starting at a BMI between 15 and 20 kg/m(2) in the Maltese and Indian populations compared to 25 kg/m(2) in Europeans.Conclusion/interpretation. The effect of BMI on the age-adjusted prevalence of Type 2 diabetes was modified by ethnicity with considerably lower thresholds in Indian and Maltese subjects compared to those from the rest of Europe. This difference should be reflected in national and international recommendations regarding "optimal" BMI.