An analytical solution simulating growth of Lewy bodies.
An analytical solution simulating growth of Lewy bodies.
复制标题
模拟路易体生长的解析解。
DOI：
10.1093/imammb/dqac006
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kuznetsov,AndreyV
中科院分区：
文献类型：
--
作者：
Kuznetsov,IvanA;Kuznetsov,AndreyV
本文提出了一个模拟路易体生长的最小模型。据我们所知，这是第一个模拟LB生长的模型。LB被认为是由一个中心的球形核心，这是由膜碎片和各种功能失调的细胞内细胞器，和一个晕，这是由α-突触核蛋白（α-syn）纤维。膜碎片和α-syn单体被假定在索马中以恒定速率产生。用Finke-Watzky模型模拟了核和晕的生长过程。分析（封闭形式）的解决方案描述的核心和晕的增长。对模型参数进行了敏感性分析。
This paper reports a minimal model simulating the growth of a Lewy body (LB). To the best of our knowledge, this is the first model simulating LB growth. The LB is assumed to consist of a central spherical core, which is composed of membrane fragments and various dysfunctional intracellular organelles, and a halo, which is composed of alpha-synuclein (α-syn) fibrils. Membrane fragments and α-syn monomers are assumed to be produced in the soma at constant rates. The growth of the core and the halo are simulated by the Finke–Watzky model. Analytical (closed-form) solutions describing the growth of the core and the halo are obtained. A sensitivity analysis in terms of model parameters is performed.