Association and Haplotype Analysis of Prostate Stem Cell Antigen with Gastric Cancer in Tibetans
Association and Haplotype Analysis of Prostate Stem Cell Antigen with Gastric Cancer in Tibetans
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DOI：
10.1089/dna.2009.0960
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发表时间：
2010-06-01
影响因子：
3.1
通讯作者：
Zhang, ChongJie
中科院分区：
文献类型：
--
作者：
Ou, JianFeng;Li, Kang;Zhang, ChongJie
已知遗传因素在胃癌的发生发展中起重要作用。前列腺干细胞抗原(PSCA)在弥漫型GC中有表达，在日本和韩国人群中，PSCA变异与弥漫型GC的易感性有关。本研究旨在探讨藏族人群中PSCA基因多态性与GC的关系。采用聚合酶链式反应/连接酶检测反应试验，分析了196例藏族胃癌患者和246例正常对照的PSCA基因单核苷酸多态性。PSCA基因rs2294008C/T多态与胃癌易感性显著相关。与CC基因相比，CT基因携带者患胃癌的风险显著增加(优势比[OR]=1.50；95%可信区间[CI]，1.01~2.23)。携带T等位基因的患者发生胃癌的风险显著高于携带C等位基因的患者(OR=1.34；95%CI，1.00~1.79)。单倍型分析显示，CA单倍型与CG单倍型相比，胃癌风险显著降低(OR=0.47；95%CI，0.24~0.93)。结果提示，藏族人群中PSCA基因多态性可能与GC相关。
Genetic factors are known to be important in the development of gastric cancer (GC). Prostate stem cell antigen (PSCA) has been shown to be expressed in diffuse-type GC, and PSCA variation is associated with susceptibility to diffuse-type GC in Japanese and Korean populations. The aim of this study was to investigate the association between PSCA gene polymorphisms and GC in a Tibetan population. We analyzed single-nucleotide polymorphisms of the PSCA gene in 196 patients with GC and 246 controls in a Tibetan population, using a polymerase chain reaction/ligase detection reaction test. The rs2294008 C/T polymorphism of the PSCA gene was significantly associated with the susceptibility to GC. The CT genotype was associated with a significantly higher risk of GC when compared with the CC genotype (odds ratio [OR] = 1.50; 95% confidence interval [CI], 1.01-2.23). Patients carrying the T allele had a significantly higher risk for developing GC compared with individuals carrying the C allele (OR = 1.34; 95% CI, 1.00-1.79). Haplotype analyses showed that CA haplotype was associated with a significantly decreased risk of GC when compared with the CG haplotype (OR = 0.47; 95% CI, 0.24-0.93). Our data indicate that PSCA gene polymorphisms may be associated with GC in Tibetans.