Quantitative three-dimensional ultrashort echo time cones imaging of the knee joint with motion correction.
Quantitative three-dimensional ultrashort echo time cones imaging of the knee joint with motion correction.
复制标题
具有运动校正的膝关节定量三维超短回波时间锥成像。
DOI：
10.1002/nbm.4214
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发表时间：
2020
影响因子：
2.9
通讯作者：
Ma,Ya-Jun
中科院分区：
文献类型：
--
作者：
Wu,Mei;Zhao,Wei;Wan,Lidi;Kakos,Lena;Li,Liang;Jerban,Saeed;Jang,Hyungseok;Chang,EricY;Du,Jiang;Ma,Ya-Jun
膝关节退行性变涉及关节的所有主要组织。然而，传统的MRI序列只能检测到长T2组织如浅表软骨的信号，而深层软骨、半月板、韧带、肌腱和骨骼的信号很少。开发新的序列来检测膝关节所有主要组织的信号是非常必要的。我们旨在开发一种全面定量的三维超短回波时间（3D UTE）锥体成像方案，用于真正的“全关节”评估膝关节退变。该方案包括用于t1映射的3D UTE锥实际翻转角成像（3D UTE‐cone‐AFI），用于T2*映射的脂肪抑制的多回波UTE‐cone，用于AdiabT1ρ映射的绝热制备的UTE‐cone，以及用于MT比（MTR）和大分子质子分数(f)建模的UTE‐cone磁化转移（UTE‐cone‐MT）。使用弹性配准技术来补偿扫描过程中的运动。对登记数据进行定量数据分析。三个膝关节标本和15名志愿者在3 t时进行了评估。弹性运动校正算法在校正与相对较长的扫描时间相关的运动伪影方面效果良好。所有UTE‐cone生物标记物的曲线拟合都得到了很大的改善，均方根误差大大降低。报告15例健康志愿者膝关节组织的平均T1、T2*、AdiabT1ρ、MTR和f。三维UTE‐锥体定量成像技术（即T1， T2*, AdiabT1ρ， MTR和MT建模）与弹性运动校正一起提供了膝关节短T2和长T2组织的松弛时间，MTR和f的稳健体积测量。
Knee degeneration involves all the major tissues in the joint. However, conventional MRI sequences can only detect signals from long T2 tissues such as the superficial cartilage, with little signal from the deep cartilage, menisci, ligaments, tendons and bone. It is highly desirable to develop new sequences that can detect signal from all major tissues in the knee.We aimed to develop a comprehensive quantitative three‐dimensional ultrashort echo time (3D UTE) cones imaging protocol for a truly “whole joint” evaluation of knee degeneration. The protocol included 3D UTE cones actual flip angle imaging (3D UTE‐Cones‐AFI) for T1mapping, multiecho UTE‐Cones with fat suppression for T2* mapping, UTE‐Cones with adiabatic T1ρ(AdiabT1ρ) preparation for AdiabT1ρmapping, and UTE‐Cones magnetization transfer (UTE‐Cones‐MT) for MT ratio (MTR) and modeling of macromolecular proton fraction (f). An elastix registration technique was used to compensate for motion during scans. Quantitative data analyses were performed on the registered data. Three knee specimens and 15 volunteers were evaluated at 3 T.The elastix motion correction algorithm worked well in correcting motion artifacts associated with relatively long scan times. Much improved curve fitting was achieved for all UTE‐Cones biomarkers with greatly reduced root mean square errors. The averaged T1, T2*, AdiabT1ρ, MTR and f for knee joint tissues of 15 healthy volunteers were reported.The 3D UTE‐Cones quantitative imaging techniques (ie, T1, T2*, AdiabT1ρ, MTR and MT modeling) together with elastix motion correction provide robust volumetric measurement of relaxation times, MTR and f of both short and long T2tissues in the knee joint.