Theoretical study of the effects of vascular smooth muscle contraction on strain and stress distributions in arteries
Theoretical study of the effects of vascular smooth muscle contraction on strain and stress distributions in arteries
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DOI：
10.1114/1.191
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发表时间：
1999-07-01
影响因子：
3.8
通讯作者：
Hayashi, K
中科院分区：
文献类型：
--
作者：
Rachev, A;Hayashi, K
为了研究血管平滑肌收缩和舒张对血管壁应变和应力分布的影响，建立了血管平滑肌收缩和舒张的数学模型。假设动脉是由非线性不可压缩弹性材料制成的正交各向异性厚壁管。考虑到平滑肌的收缩在壁中产生主动周向应力，使用文献中可用的数据进行了数值研究。所获得的结果表明，平滑肌收缩影响存在于从动脉切下的环段中的残余应变，并且暴露于无外部负荷。当环形试样被径向切割时，它以一个张开角弹开。预测的单调增加的开口角增加肌张力与最近的实验结果在文献中报道。结果表明，生理条件下存在的基础肌张力降低了动脉壁的应变梯度，并产生了接近均匀的应力分布。在血压暂时变化时，由压力升高引起的肌张力的增加倾向于恢复动脉壁的周向应变分布，并将由压力引起的壁切应力维持在正常水平。(C)1999年生物医学工程学会。【S0090-6964（99）00404-X】。
To study the effects of smooth muscle contraction and relaxation on the strain and stress distribution in the vascular wall, a mathematical model was proposed. The artery was assumed to be a thick-walled orthotropic tube made of nonlinear, incompressible elastic material. Considering that the contraction of smooth muscle generates an active circumferential stress in the wall, a numerical study was performed using data available in the literature. The results obtained showed that smooth muscle contraction affects the residual strains which exist in a ring segment cut out from the artery and exposed to no external load. When the ring specimen is cut radially, it springs open with an opening angle. The predicted monotonic increase of the opening angle with increasing muscular tone was in agreement with recent experimental results reported in the literature. It was shown that basal muscular tone, which exists under physiological conditions, reduces the strain gradient in the arterial wall and yields a near uniform stress distribution. During temporary changes in blood pressure, the increase in muscular tone induced by elevated pressure tends to restore the distribution of circumferential strain in the arterial wall, and to maintain the dow-induced wall shear stress to normal level. (C) 1999 Biomedical Engineering Society. [S0090-6964(99)00404-X].