Age of illness onset and schizophrenic symptomatology during an inpatient washout period.
Age of illness onset and schizophrenic symptomatology during an inpatient washout period.
复制标题
住院患者清洗期间的发病年龄和精神分裂症症状。
DOI：
10.1016/0920-9964(96)00005-9
复制
发表时间：
1996
影响因子：
4.5
通讯作者：
Janicak,PG
中科院分区：
文献类型：
--
作者：
Sharma,RP;Dowd,SM;Davis,JM;Janicak,PG
作者在一个急性精神分裂症患者的样本中研究了发病年龄和耐受无药物治疗期的能力之间的关系。患者被送入住院研究单位治疗急性和复发性精神症状。入院后停止既往药物治疗，以进行临床研究和行为评估，不受药物副作用的影响。发病年龄与医院洗脱时间呈显著正相关。此外，发病年龄与BPRS总分和BPRS敌对/怀疑因子在洗脱结束时测量显着相关。我们的研究结果表明，早发性精神分裂症恶化更迅速，在急性发作比他们的年龄晚发病的同行。
The authors examine the relationship between the age of illness onset and the ability to tolerate a medication-free period in a sample of acutely ill schizophrenic patients. Patients were admitted to an inpatient research unit for the treatment of acute and recurrent psychiatric symptoms. Prior medications were discontinued upon admission to the unit for purposes of clinical research and behavioral assessment uncontaminated by medication side effects. The age of illness onset was significantly and positively correlated with the duration of hospital washout. Furthermore, age of illness onset was significantly correlated with the BPRS total score and the BPRS hostility/suspiciousness factor measured at the end of washout. Our results suggest that early onset schizophrenics deteriorate more rapidly in an acute episode than do their later age of onset counterparts.