LIVER DAMAGE AND SEX HORMONES IN CHRONIC MALE ALCOHOLICS
LIVER DAMAGE AND SEX HORMONES IN CHRONIC MALE ALCOHOLICS
复制标题
慢性男性酗酒者的肝损伤和性激素
作者：
M. Välimäki;M. Salaspuro;M. Härkönen;R. Ylikahri
在戒酒7-14天后，研究了13名经组织学证实患有酒精性肝硬化的慢性男性酗酒者和16名具有类似饮酒史的非酒精性慢性酗酒者的激素状态。低水平的血浆睾酮和中度升高的血浆LH浓度见于阿尔茨海默病患者，但非阿尔茨海默病患者中未观察到。在糖尿病患者中，睾酮值与血清白蛋白和血浆凝血酶原水平呈正相关。两组LH和FSH分泌对LHRH刺激的反应相似，基础FSH值也相似。所有患者的血浆雌二醇浓度均在正常范围内。然而，在两组中，血浆PRL和雌酮的基础水平均升高，在妊娠组中显著高于非妊娠组。后一组的特点是由一个夸张的反应，催乳素分泌TRH刺激。两组的SHBG浓度均在正常范围内。
The hormonal status of thirteen chronic male alcoholics with histologically proved alcoholic liver cirrhosis and that of sixteen non‐cirrhotic chronic alcoholics with a similar drinking history were studied after the abstinence of 7–14 days. Low levels of plasma testosterone and moderately elevated concentrations of plasma LH were seen in cirrhotics but not in non‐cirrhotics. In cirrhotics, testosterone values showed positive correlations with levels of serum albumin and plasma prothrombin. The responses of LH and FSH secretions to LHRH stimulation were similar in the two groups as were the basal FSH values. Plasma concentrations of oestradiol were within normal limits in all patients. In both groups however, basal levels of plasma PRL and oestrone were increased, significantly more so in cirrhotics than in non‐cirrhotics. The latter group was characterized by an exaggerated response of PRL secretion to TRH stimulation. SHBG concentrations were within normal range in both groups.