AOPPs and the progression of kidney disease.
AOPPs and the progression of kidney disease.
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DOI：
10.1038/kisup.2014.19
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发表时间：
2014-11
影响因子：
5.5
通讯作者：
Nie J
中科院分区：
文献类型：
--
作者：
Cao W;Hou FF;Nie J
晚期氧化蛋白产物（Advanced oxidation protein products，AOPPs）是血浆蛋白在氧化应激过程中与氯代氧化剂反应形成的含二酪氨酸的交联蛋白产物，在体内常由白蛋白携带。血浆和肾脏AOPP蓄积是慢性肾病（CKD）患者的常见病理学发现。此外，AOPP蓄积是CKD患者心血管事件（CVD）的独立危险因素。临床和实验研究表明，AOPP通过氧化还原依赖性途径参与进行性肾病如肾小球硬化、间质纤维化和肾小管萎缩的结构变化。越来越多的证据支持AOPP作为一类新的肾脏致病介质在CKD进展中的作用。本文就AOPPs的形成、在CKD发病中的作用及其机制作一简要综述。
Advanced oxidation protein products (AOPPs) are the dityrosine-containing and crosslinking protein products formed during oxidative stress by reaction of plasma protein with chlorinated oxidants, and often carried by albumin in vivo. Accumulation of plasma and renal AOPPs is a common pathologic finding in chronic kidney disease (CKD) patients. Moreover, AOPP accumulation is an independent risk factor for cardiovascular events (CVDs) in CKD. Clinical and experimental studies indicate that AOPPs are involved in the structural changes of progressive nephropathies such as glomerulosclerosis, interstitial fibrosis, and tubular atrophy via the redox-dependent pathway. Mounting evidence supports the role of AOPPs as a new class of renal pathogenic mediators in the progression of CKD. This mini review describes the formation of AOPPs, the involvement of AOPPs in CKD pathogenesis, and the underlying mechanisms.