ALCOHOLIC LIVER-INJURY - DEFENESTRATION IN NONCIRRHOTIC LIVERS - A SCANNING ELECTRON-MICROSCOPIC STUDY
ALCOHOLIC LIVER-INJURY - DEFENESTRATION IN NONCIRRHOTIC LIVERS - A SCANNING ELECTRON-MICROSCOPIC STUDY
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DOI：
10.1002/hep.1840070117
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发表时间：
1987-01-01
期刊：
影响因子：
13.5
通讯作者：
HENRIKSEN, JH
中科院分区：
文献类型：
--
作者：
HORN, T;CHRISTOFFERSEN, P;HENRIKSEN, JH
用扫描电镜观察了15例慢性酒精中毒患者肝窦内皮细胞的窗孔形成。与非酒精性药物相比，通过光学显微镜判断，在有和无3区纤维化的活组织检查中，在腺泡3区观察到窦状窦衬里壁的窗孔数量和孔隙度（窗孔面积分数）显著减少。本研究中所示的孔隙率的显著降低可能影响血液肝细胞交换，并有助于酒精诱导的肝损伤。
The fenestration of hepatic sinusoidal endothelial cells in 15 needle biopsies obtained from chronic alcoholics without cirrhosis was studied by scanning electron microscopy. As compared to nonalcholics, a significant reduction in the number of fenestrae and porosity of the sinusoidal lining wall (fractional area of fenestrae) was observed in acinar Zone 3, both in biopsies with and without Zone 3 fibrosis as judged by light microscopy. A significant reduction of porosity as shown in this study may influence the blood hepatocytic exchange and contribute to the alcohol-induced liver injury.