DISTRIBUTION AND REDOX STATE OF UBIQUINONES IN RAT AND HUMAN TISSUES
DISTRIBUTION AND REDOX STATE OF UBIQUINONES IN RAT AND HUMAN TISSUES
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DOI：
10.1016/0003-9861(92)90511-t
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发表时间：
1992-06-01
影响因子：
3.9
通讯作者：
ERNSTER, L
中科院分区：
文献类型：
--
作者：
ABERG, F;APPELKVIST, EL;ERNSTER, L
研究了泛醌在大鼠和人体组织中的分布和氧化还原状态。采用快速提取程序和直接进样到HPLC上。在模型实验中发现，在死后组织中，泛醌既不发生氧化也不发生还原。在大鼠中，在心脏、肾脏和肝脏中发现了最高浓度的泛醌-9（130-200 μg/g）。在脑、脾和肠中，三分之一和在其他组织中，总泛醌的10-20%含有10个异戊二烯单元。在人体组织中，泛醌-10也以最高浓度存在于心脏、肾脏和肝脏中（60-110 μg/g），并且在所有组织中，总泛醌的2-5%含有9个异戊二烯单位。除脑和肺外，在人体组织中可观察到70- 100%的高水平降低。大鼠中的降低程度显示出类似的模式，但通常较低。
The distribution and redox state of ubiquinone in rat and human tissues have been investigated. A rapid extraction procedure and direct injection onto HPLC were employed. It was found in model experiments that in postmortem tissue neither oxidation nor reduction of ubiquinone occurs. In rat the highest concentrations of ubiquinone-9 were found in the heart, kidney, and liver (130–200 μg/g). In brain, spleen, and intestine one-third and in other tissues 10–20% of the total ubiquinone contained 10 isoprene units. In human tissues ubiquinone-10 was also present at highest concentrations in heart, kidney, and liver (60–110 μg/g), and in all tissues 2–5% of the total ubiquinone contained 9 isoprene units. High levels of reduction, 70–100%, could be observed in human tissues, with the exception of brain and lung. The extent of reduction displayed a similar pattern in rat, but was generally lower.