SEX-DEPENDENT ALTERATION IN CORTISOL RESPONSE TO ENDOGENOUS ADRENOCORTICOTROPIN
SEX-DEPENDENT ALTERATION IN CORTISOL RESPONSE TO ENDOGENOUS ADRENOCORTICOTROPIN
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DOI：
10.1210/jc.77.1.234
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发表时间：
1993-07-01
影响因子：
5.8
通讯作者：
ETMAN, BHB
中科院分区：
文献类型：
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作者：
ROELFSEMA, F;VANDENBERG, G;ETMAN, BHB
我们调查了两组五名健康成年男性和女性受试者的ACTH和皮质醇分泌模式。以10分钟的间隔获得血浆样品，持续24小时，并通过多参数去卷积技术分析脉动激素释放。男性受试者的ACTH分泌高于女性受试者;每24小时的产生率为男性139 +/- 7 pmol/L分布体积，女性89 +/- 11 pmol/L分布体积（P = 0.007）。皮质醇分泌在性别之间没有显著差异;在雄性中，24小时分泌速率为2807 +/- 239 nmol/L分布体积，在雌性中，为2970 +/- 411 nmol/L分布体积（P = NS）。通过去卷积分析确定的每24小时ACTH分泌脉冲数，雄性为16.2 +/- 1.4，雌性为19.6 +/- 2.0（P = NS）。皮质醇脉冲的数量或ACTH和皮质醇的计算半衰期没有性别差异。ACTH和皮质醇脉冲显着一致的皮质醇滞后时间为10分钟，证明了概率分析和自回归模型的交叉相关。基于女性皮质醇脉冲高度对ACTH脉冲高度的回归截距显著不同于男性（P < 0.001），以及女性皮质醇与ACTH产生率的比率高于男性（P = 0.013），我们认为女性肾上腺皮质在糖皮质激素产生方面比男性对ACTH更敏感。因此，在男性和女性中获得相等的每日皮质醇分泌率，而男性的ACTH释放量更大。
We have investigated ACTH and cortisol secretion patterns in two groups of five healthy adult male and female subjects. Plasma samples were obtained at 10-min intervals for 24 h, and pulsatile hormone release was analyzed by a multiparameter deconvolution technique. ACTH secretion was greater in male than female subjects; the production rate per 24 h was 139 +/- 7 pmol/L distribution volume in males, and 89 +/- 11 pmol/L distribution volume in females (P = 0.007). Cortisol secretion did not differ significantly between sexes; in males, the 24-h secretion rate was 2807 +/- 239 nmol/L distribution volume, and in females, it was 2970 +/- 411 nmol/L distribution volume (P = NS). The number of ACTH secretory pulses per 24 h, as determined by deconvolution analysis, was 16.2 +/- 1.4 in males and 19.6 +/- 2.0 in females (P = NS). There were no sex differences in the number of cortisol pulses or the calculated half-lives of ACTH and cortisol. ACTH and cortisol pulses were significantly concordant at a cortisol lag time of 10 min, as demonstrated by probability analysis and cross-correlation with autoregressive modeling. Based on a significantly different regression intercept of cortisol pulse height on ACTH pulse height in women than in men (P < 0.001) and a higher ratio of cortisol to ACTH production rates in women than in men (P = 0.013), we suggest that the female adrenal cortex is more responsive to ACTH than its male counterpart in terms of glucocorticoid production. Consequently, equivalent daily cortisol secretion rates are attained in men and women at the expense of greater ACTH release in men.