Head and neck teratomas in children-A series of 23 cases at Great Ormond Street Hospital
Head and neck teratomas in children-A series of 23 cases at Great Ormond Street Hospital
复制标题
DOI：
10.1016/j.ijporl.2015.07.042
复制
发表时间：
2015-12-01
影响因子：
1.5
通讯作者：
Hartley, Benjamin E. J.
中科院分区：
文献类型：
--
作者：
Alexander, Victoria Rebecca Carol;Manjaly, Joseph George;Hartley, Benjamin E. J.
目的：头颈部畸胎瘤少见，恶变更少见。这是一份报告，详细介绍了所有的畸胎瘤治疗的耳，鼻，喉或颅面团队在过去28年在我们的机构。检查常见的表现和放射学特征，以及我们的成功率相比，目前的literature.Method：回顾性分析的所有情况下，提出我们的机构与头部和颈部畸胎瘤进行了分析。收集有关以下特征的数据：产前病史、临床特征、生物血清标志物、放射学和病理学特征。结果：23例中，颈部8例，鼻咽6例，甲状腺5例，胸腺2例，颞叶2例。1例恶变。大多数儿童在出生时出现呼吸窘迫，5例在产前发现，1例在10岁时出现。所有患者均行手术治疗，其中20例患者完全切除。没有发生临床复发，但进一步手术进行放射学怀疑残留disease in one case.Discussion：这是最大的详细的病例系列文献中关于头部和颈部畸胎瘤。说明这通常是一种良性疾病过程中的疾病在头部和颈部区域，并有一个良好的长期预后手术后。在不完全切除的情况下，仔细、细致的放射成像随访和多学科团队的方法是一种安全可行的替代方法。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Objective: Head and neck teratomas are rare and malignant change is rarer still. This is a report detailing all of the teratomas treated by the ear, nose and throat or craniofacial teams over the last 28 years at our institution. Examining the common presenting and radiological features as well as our success rates compared to the current literature.Method: A retrospective review of all cases presenting to our institution with a head and neck teratoma were analysed. Data regarding the following characteristics were collected: antenatal history, clinical features, biological serum makers, radiological and pathological characteristics. Surgical treatment, rates of reoccurrence and the degree of post-operative follow up were also analysed.Results: 23 cases in total were included: 8 cervical, 6 nasopharyngeal, 5 thyroid, 2 thymus, 2 temporal. One had malignant change. The majority of children presented at birth with respiratory distress, 5 cases were picked up antenatally and one case presented at 10 years of age. All were treated surgically; with complete excision in 20 patients. No clinical recurrence occurred but further surgery was performed for radiologically suspected residual disease in one case.Discussion: This is the largest detailed case series in literature in regard to head and neck teratomas. Illustrating that this is frequently a benign disease process disease in the head and neck region and has an excellent long term prognosis following surgery. In the situation of incomplete resection careful meticulous follow up with radiological imaging and a multidisciplinary team approach is a safe and viable alternative. (C) 2015 Elsevier Ireland Ltd. All rights reserved.