Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins
Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins
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DOI：
10.1016/j.bbrc.2012.01.120
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发表时间：
2012-02-24
影响因子：
3.1
通讯作者：
Goto, Sataro
中科院分区：
文献类型：
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作者：
Kawakami, Kyojiro;Nakamura, Akihiro;Goto, Sataro
我们研究了饮食限制（DR）相关的大鼠肝脏组蛋白H3的位点特异性乙酰化的变化，以探索可能的联系，组蛋白修饰和沉默调节蛋白水平与DR的抗衰老作用。在H3的赖氨酸残基9，27和56的乙酰化是20-30%，高自由采食相比，在DR动物。SIRT 6是组蛋白去乙酰化酶之一，DR可显著降低SIRT 6，从而可能参与组蛋白乙酰化的增加。我们的研究结果表明，通过增加组蛋白乙酰化上调染色质活性是DR的抗衰老作用机制。（C）2012 Elsevier Inc. All rights reserved.
We studied dietary restriction (DR) related changes of site-specific acetylation of histone H3 in rat livers to explore a possible link to histone modifications and sirtuin levels with anti-aging effects of DR. The acetylation at lysine residue 9, 27 and 56 in H3 was 20-30% higher in DR animals compared with ad libitum fed counterparts. SIRT6, one of histone deacetylases, was significantly decreased by DR and thereby may be involved in an increase in the histone acetylation. Our findings suggest that upregulation of chromatin activities through increased histone acetylation is a mechanism of anti-aging effects of DR. (C) 2012 Elsevier Inc. All rights reserved.