Integrated view of the human chromosome X-centric proteome project.
Integrated view of the human chromosome X-centric proteome project.
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人类 X 染色体中心蛋白质组项目的综合视图。
DOI：
10.1021/pr300844p
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Goshima N.
中科院分区：
文献类型：
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作者：
Yamamoto T;Nakayama K;Hirano H;Tomonaga T;Ishihama Y;Yamada T;Kondo T,Kodera Y;Sato Y;Araki N;Mamitsuka H;Goshima N.
本文介绍了日本X染色体计划联盟（JCP）的人类X染色体中心蛋白质组计划。雌性哺乳动物两条染色体之一的失活和神经/免疫系统/肿瘤/睾丸相关基因的积累是X染色体的特征。在这个X染色体项目中，从X染色体上的基因翻译的蛋白质的信息是通过质谱和基于抗体的蛋白质组学收集的。还提供了以下资源的信息：蛋白质的抗体翻译和全长cDNA转录从染色体X基因的重组蛋白。该联盟旨在提供以下工具来搜索文献中有用的抗体（Antibody Ranker），在微阵列数据库中找到基因表达位点（Transcript Localizer），并进行高级MRM分析（基于信息的MRM）。
This article introduces how the human chromosome X-centric proteome project is carried out by the Japan Chromosome X Project Consortium. The inactivation of one of two chromosomes in female mammals and accumulation of genes related to neural/immune systems/tumor/testis are characteristic of chromosome X. In this Chromosome X Project, information on proteins translated from genes on chromosome X is collected by both mass spectrometry- and antibody-based proteomics. Information on the following resources is also provided: antibodies to proteins translated and full-length cDNAs transcripted from the chromosome X genes for recombinant proteins. The consortium aims to provide the following tools to search useful antibodies in the literature (Antibody Ranker), to find gene expression sites in microarray databases (Transcript Localizer) and to do advanced MRM analysis (information-based MRM).