Hormonal properties of transplanted pituitary tumors and their relation to the pituitary gland.
Hormonal properties of transplanted pituitary tumors and their relation to the pituitary gland.
复制标题
移植性垂体瘤的激素特性及其与垂体的关系。
作者：
R. Macleod;M. C. Smith;G. W. Dewitt
垂体瘤 MtTW5 分泌生长激素和催乳素，导致激素依赖性乳腺肿瘤的生长和乳腺的发育。这种肿瘤的一种变体已经出现，它缺乏催乳活性，但保留了生长激素活性。母体肿瘤（MtTW5）和另一种泌乳素分泌肿瘤（7315a）导致乳腺对 131I 的摄取大幅增加，但这在携带肿瘤变异株（StW5）的大鼠中并不明显。通过计算每 0.0306 mm2 黄体细胞核的数量来证明 MtTW5 和 7315a 分泌的黄体营养激素。携带这些肿瘤的大鼠的卵巢细胞核比非肿瘤大鼠或携带 StW5 的大鼠少 40%。 MtTW5 和 StW5 分泌的生长激素增加，表现为身体生长速度加快和胫骨骨骺软骨板增大。携带 MtTW5 和 StW5 的大鼠每 100 克体重的垂体重量显着低于非肿瘤大鼠......
Pituitary tumor MtTW5, which secretes growth hormone and prolactin, causes growth of a hormone-dependent mammary tumor and development of the mammary gland. A variant of this tumor has arisen which is devoid of mammogenic activity but has retained somatotrophic activity. The parent tumor (MtTW5) and another prolactin-secreting tumor (7315a) caused large increases in the uptake of 131I by the mammary gland, but this was not apparent in rats bearing the variant strain of tumor (StW5). The luteotrophic hormone secreted by MtTW5 and 7315a was demonstrated by counting the number of corpus luteum cell nuclei per 0.0306 mm2. Ovaries from rats bearing these tumors had 40% fewer nuclei than nontumor rats or those bearing StW5. Increased somatotrophic hormone secreted by MtTW5 and StW5 was demonstrated by an increased rate of body growth and an enlarged tibia epiphysial cartilage plate. Pituitary gland weight expressed per 100 g body weight was significantly less in rats bearing MtTW5 and StW5 than in nontumor rats...