ETHANOL-INDUCED LOCOMOTOR-ACTIVITY - INVOLVEMENT OF CENTRAL NICOTINIC ACETYLCHOLINE-RECEPTORS
ETHANOL-INDUCED LOCOMOTOR-ACTIVITY - INVOLVEMENT OF CENTRAL NICOTINIC ACETYLCHOLINE-RECEPTORS
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DOI：
10.1016/0361-9230(92)90023-q
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发表时间：
1992-08-01
影响因子：
3.8
通讯作者：
ENGEL, JA
中科院分区：
文献类型：
--
作者：
BLOMQVIST, O;SODERPALM, B;ENGEL, JA
乙醇和尼古丁有许多共同的精神药理学作用，这可以解释为什么这些化合物的共同管理往往是在个人中观察到的。在目前的小鼠研究中，低剂量尼古丁以复杂的方式改变了不同剂量乙醇的自发活动（LMA）刺激作用，而四元尼古丁类似物四甲基铵则没有。血脑屏障渗透尼古丁拮抗剂美加明（2.0和4.0 mg/kg），但不是四元尼古丁拮抗剂六甲铵（4.0和8.0 mg/kg），部分抵消了乙醇（3.0 g/kg）的LMA刺激作用，剂量本身没有LMA降低作用。美卡拉明2.0和4.0mg/kg可部分拮抗乙醇3.0g/kg引起的小鼠脑内二羟苯乙酸（DOPAC）/多巴胺（DA）比值的增加。这些结果表明，部分的LMA和DA营业额增加乙醇的影响是通过激活中枢烟碱乙酰胆碱受体介导的。
Ethanol and nicotine have many psychopharmacological effects in common, which could explain why coadministration of these compounds often is observed in individuals. In the present study in mice, low doses of nicotine in a complex manner altered the locomotor activity (LMA) stimulatory effect of different doses of ethanol, whereas the quarternary nicotine analog tetramethylammonium did not. The blood-brain-barrier-penetrating nicotine antagonist mecamylamine (2.0 and 4.0 mg/kg), but not the quarternary nicotine antagonist hexamethonium (4.0 and 8.0 mg/kg), partly counteracted the LMA stimulatory effect of ethanol (3.0 g/kg) in doses having no LMA reducing effects per se. Furthermore, the dihydroxyphenylacetic acid (DOPAC)/dopamine (DA) quotient increase in mouse brain after ethanol 3.0 g/kg was partly antagonized by mecamylamine 2.0 and 4.0 mg/kg. These results suggest that part of the LMA and DA turnover-increasing effect of ethanol is mediated via activation of central nicotinic acetylcholine receptors.